Protein origami and aging

If I were to add a 15th theory of aging to this Anti-Aging Firewalls treatise, it would possibly be Misfoldings of proteins.  The basic notion is that stress often leads to the misfolding of proteins, a process that can accelerate with age creating vulnerability to a number of disease and dysfunctional conditions.  Misfolded proteins cannot perform their intended functions, can create active mischief and probably contribute to aging in multiple ways.  This is a relatively new and complex area of molecular biology that is to a large extent still unexplored.  I have posted a long and rather technical note on the subject here in my Antiaging Firewalls Treatise.

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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