Comments on: Trojan-horse stem cells might offer an important new cancer therapy http://www.anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/ A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. Tue, 07 Feb 2012 16:23:41 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: CAR adoptive stem cell immunotherapy– an emerging new weapons against cancers and other incurable diseases | AGING SCIENCES – Anti-Aging Firewalls http://www.anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/#comment-56893 CAR adoptive stem cell immunotherapy– an emerging new weapons against cancers and other incurable diseases | AGING SCIENCES – Anti-Aging Firewalls Sun, 27 Nov 2011 20:49:29 +0000 http://anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/#comment-56893 [...] A closely related cancer therapy is also based on targeting cancer cells via surface antigens, but with antibodies delivering deadly payloads.  The October 2011 publication Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates reports “To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens.”   I wrote about such a stem cell payload approach back in May 2009 in the blog entry Trojan-horse stem cells might offer an important new cancer therapy. [...] [...] A closely related cancer therapy is also based on targeting cancer cells via surface antigens, but with antibodies delivering deadly payloads.  The October 2011 publication Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates reports “To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens.”   I wrote about such a stem cell payload approach back in May 2009 in the blog entry Trojan-horse stem cells might offer an important new cancer therapy. [...]

]]> By: admin http://www.anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/#comment-1338 admin Thu, 21 May 2009 18:58:37 +0000 http://anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/#comment-1338 What a good question. It appears that curcumin, resveratrol and perhaps many of the other phyto-substances in the anti-cancer firewall work through the same mechanism as the TRAIL-loaded stem cells do. They induce differential apoptosis in cancer cells via TRAIL working on death receptors 4 and 5. See http://books.google.com/books?id=NP8JZOF5JtUC&pg=PA141&lpg=PA141&dq=resveratrol+TRAIL&source=bl&ots=mLIgIUrau4&sig=NVjca7ym8lcZBJ2tdXbphnqvbnM&hl=en&ei=RKEVSvP5MpSS9QTysZDHAg&sa=X&oi=book_result&ct=result&resnum=1 and http://carcin.oxfordjournals.org/cgi/content/full/27/10/2008 In other words, taking these substances initiates the same death-creating biomolecular chain in cancer cells that the TRAIL-loaded stem cells do. As to your direct question about signaling, I don't know the answer but would like to. What a good question. It appears that curcumin, resveratrol and perhaps many of the other phyto-substances in the anti-cancer firewall work through the same mechanism as the TRAIL-loaded stem cells do. They induce differential apoptosis in cancer cells via TRAIL working on death receptors 4 and 5. See http://books.google.com/books?id=NP8JZOF5JtUC&pg=PA141&lpg=PA141&dq=resveratrol+TRAIL&source=bl&ots=mLIgIUrau4&sig=NVjca7ym8lcZBJ2tdXbphnqvbnM&hl=en&ei=RKEVSvP5MpSS9QTysZDHAg&sa=X&oi=book_result&ct=result&resnum=1 and http://carcin.oxfordjournals.org/cgi/content/full/27/10/2008
In other words, taking these substances initiates the same death-creating biomolecular chain in cancer cells that the TRAIL-loaded stem cells do.

As to your direct question about signaling, I don’t know the answer but would like to.

]]> By: Res http://www.anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/#comment-1312 Res Wed, 20 May 2009 19:40:36 +0000 http://anti-agingfirewalls.com/2009/05/20/trojan-horse-stem-cells-might-offer-an-important-new-cancer-therapy/#comment-1312 interesting new methodology. / conjecture that this is because cancers excrete signaling molecules that cause the circulating MSCs to home in on them, a strategy cancers use to achieve rapid growth(ref). / Does any of the firewall substance blocks the molecule signaling? Thanks Vince as always interesting new methodology.

/ conjecture that this is because cancers excrete signaling molecules that cause the circulating MSCs to home in on them, a strategy cancers use to achieve rapid growth(ref). /

Does any of the firewall substance blocks the molecule signaling?

Thanks Vince as always

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