Naked complexity

In this blog and in my treatise Anti-Aging Firewalls – The Science And Technology Of Longevity I try to steer a mid course between scientific over-simplification and loosing readers because the content is too technical for them to fathom.  I am aware that many readers possibly have to struggle to follow the details of some of my posts.  The purpose of this particular post is to remind my reader that longevity science involves biomolecular and genetic complexity that is much deeper than what I discuss, or for that matter, that I am competent to discuss. 

It is pretty much agreed that extraordinary longevity will require activation of critical longevity-related cell signal transduction pathways. Yet, those pathways are incredibly complex.  As an example, here is a listing of papers in the current online issue of the Journal of Biological Chemistry having to do with Mechanisms of Signal Transduction.  I list the titles to illustrate the naked underlying complexity involved.  And there are thousands of other journals reporting research results every month of equal complexity that have potential relevance for longevity.  I am not suggesting you read these items but you might find the titles interesting for illustrating the biomolecular detail involved.  I am necessarily highly selective in what I cover in this blog. 

Subhashini Srinivasan, Fozia Mir, Jin-Sheng Huang, Fadi T. Khasawneh, Stephen C.-T. Lam, and Guy C. Le Breton The P2Y12 Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels.  J. Biol. Chem. 2009 284: 16108-16117. First Published on April 3, 2009; doi:10.1074/jbc.M809780200 [Abstract] [Full Text] [PDF] 

Matthew J. Betzenhauser, Larry E. Wagner, II, Hyung Seo Park, and David I. Yule ATP Regulation of Type-1 Inositol 1,4,5-Trisphosphate Receptor Activity Does Not Require Walker A-type ATP-binding Motifs
J. Biol. Chem. 2009 284: 16156-16163.
First Published on April 22, 2009; doi:10.1074/jbc.M109.006452 [Abstract] [Full Text] [PDF]  

Xiang Li, George S. Baillie, and Miles D. Houslay Mdm2 Directs the Ubiquitination of β-Arrestin-sequestered cAMP Phosphodiesterase-4D5.  J. Biol. Chem. 2009 284: 16170-16182. First Published on April 16, 2009; doi:10.1074/jbc.M109.008078 [Abstract] [Full Text] [PDF] [Data Supplement 1]  

Chunmei Wang, Runzi Qi, Nan Li, Zhengxin Wang, Huazhang An, Qinghua Zhang, Yizhi Yu, and Xuetao Cao Notch1 Signaling Sensitizes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Hepatocellular Carcinoma Cells by Inhibiting Akt/Hdm2-mediated p53 Degradation and Up-regulating p53-dependent DR5 Expression
J. Biol. Chem. 2009 284: 16183-16190.
First Published on April 17, 2009; doi:10.1074/jbc.M109.002105 [Abstract] [Full Text] [PDF] [Supplemental Data] 

Kam-Leung Siu, Kin-Hang Kok, Ming-Him James Ng, Vincent K. M. Poon, Kwok-Yung Yuen, Bo-Jian Zheng, and Dong-Yan Jin Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKK Complex
J. Biol. Chem. 2009 284: 16202-16209. First Published on April 20, 2009; doi:10.1074/jbc.M109.008227 [Abstract] [Full Text] [PDF]  

David Grandy, Jufang Shan, Xinxin Zhang, Sujata Rao, Shailaja Akunuru, Hongyan Li, Yanhui Zhang, Ivan Alpatov, Xin A. Zhang, Richard A. Lang, De-Li Shi, and Jie J. Zheng Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled
J. Biol. Chem. 2009 284: 16256-16263.
First Published on April 21, 2009; doi:10.1074/jbc.M109.009647 [Abstract] [Full Text] [PDF] 

Philip J. Dittmer, Jose G. Miranda, Jessica A. Gorski, and Amy E. Palmer Genetically Encoded Sensors to Elucidate Spatial Distribution of Cellular Zinc
J. Biol. Chem. 2009 284: 16289-16297.
First Published on April 10, 2009; doi:10.1074/jbc.M900501200 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Sandra Mueller, Gunnar Kleinau, Mariusz W. Szkudlinski, Holger Jaeschke, Gerd Krause, and Ralf Paschke The Superagonistic Activity of Bovine Thyroid-stimulating Hormone (TSH) and the Human TR1401 TSH Analog Is Determined by Specific Amino Acids in the Hinge Region of the Human TSH Receptor
J. Biol. Chem. 2009 284: 16317-16324.
First Published on April 22, 2009; doi:10.1074/jbc.M109.005710 [Abstract] [Full Text] [PDF]  

Alyson C. Howlett, Amy J. Gray, Jesse M. Hunter, and Barry M. Willardson Role of Molecular Chaperones in G Protein β5/Regulator of G Protein Signaling Dimer Assembly and G Protein β Dimer Specificity
J. Biol. Chem. 2009 284: 16386-16399.
First Published on April 17, 2009; doi:10.1074/jbc.M900800200 [Abstract] [Full Text] [PDF]    

Petri Ala-Laurila, M. Carter Cornwall, Rosalie K. Crouch, and Masahiro Kono The Action of 11-cis-Retinol on Cone Opsins and Intact Cone Photoreceptors
J. Biol. Chem. 2009 284: 16492-16500.
First Published on April 22, 2009; doi:10.1074/jbc.M109.004697 [Abstract] [Full Text] [PDF]    

Rosalyn P. Johnson, Ahmed F. El-Yazbi, Morgan F. Hughes, David C. Schriemer, Emma J. Walsh, Michael P. Walsh, and William C. Cole Identification and Functional Characterization of Protein Kinase A-catalyzed Phosphorylation of Potassium Channel Kv1.2 at Serine 449
J. Biol. Chem. 2009 284: 16562-16574.
First Published on April 22, 2009; doi:10.1074/jbc.M109.010918 [Abstract] [Full Text] [PDF]  

Jonathan Barroso-González, Nabil El Jaber-Vazdekis, Laura García-Expósito, José-David Machado, Rafael Zárate, Ángel G. Ravelo, Ana Estévez-Braun, and Agustín Valenzuela-Fernández The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities
J. Biol. Chem. 2009 284: 16609-16620.
First Published on April 22, 2009; doi:10.1074/jbc.M109.005835 [Abstract] [Full Text] [PDF] [Supplemental Data]  

  Mohammad Husain, Leonard G. Meggs, Himanshu Vashistha, Sonia Simoes, Kevin O. Griffiths, Dileep Kumar, Joanna Mikulak, Peter W. Mathieson, Moin A. Saleem, Luis Del Valle, Sergio Pina-Oviedo, Jin Ying Wang, Surya V. Seshan, Ashwani Malhotra, Krzysztof Reiss, and Pravin C. Singhal Inhibition of p66ShcA Longevity Gene Rescues Podocytes from HIV-1-induced Oxidative Stress and Apoptosis
J. Biol. Chem. 2009 284: 16648-16658.
First Published on April 21, 2009; doi:10.1074/jbc.M109.008482 [Abstract] [Full Text] [PDF]  

Evgeny A. Zemskov, Elena Loukinova, Irina Mikhailenko, Richard A. Coleman, Dudley K. Strickland, and Alexey M. Belkin Regulation of Platelet-derived Growth Factor Receptor Function by Integrin-associated Cell Surface Transglutaminase
J. Biol. Chem. 2009 284: 16693-16703.
First Published on April 22, 2009; doi:10.1074/jbc.M109.010769 [Abstract] [Full Text] [PDF] [Supplemental Data]   

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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