Genetics, genomics, epigenetics and epigenomics are important recurrent topics in the writing of this blog. The discussions have included many examples of longevity-related genes, “shortivity” genes, cancer and inflammation-related genes, gene silencing and gene mutations. For reference purposes I list the genes I have discussed or mentioned with pointers to the corresponding blog entries.
· “Genetic mutations in the components of telomerase (the RNA template sequence hTERC, reverse transcriptase hTERT, and Syskerin DKC1) have recently been implicated in a variety of bone marrow failure syndromes, idiopathic pulmonary fibrosis, and more recently, acute myeloid leukemia (AML)(ref).”
· “The crucial role of telomeres in cell turnover and aging is highlighted by patients with 50% of normal telomerase levels resulting from a mutation in one of the telomerase genes. Short telomeres in such patients are implicated in a variety of disorders including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis, and cancer(ref).”
· See also the blog entry Hoyeraal-Hreidarsson Syndrome and telomere dysfunction
VHL-1 gene: See the blog entry Another longevity-related biochemical pathway.
P-50/65 and NF-kappaB: See the blog entry Autoimmune diseases and lymphoma – Part II: focus on inflammation
P16 and P19 genes: See the blog entries Linking up the theories of aging and Revisiting the naked mole rat – two factors we can emulate for longevity
WFS1, CISD2, WRN and LMNA genes: See the blog entry Another rare genetic disease, and shortevity genes
LMNA gene: See the blog entry Progerin, HGPS and a possible new theory of aging.
AOX gene: This is a possibly-protective gene missing in humans. See the blog entry Gene therapy for fruit flies with Parkinson’s Disease
FRAP1 gene and mTOR: See the blog entry Longevity genes, mTOR and lifespan.
FA gene: See the blog entry
CFTR, GSTZ1_02 ,pG42R), AKR1C3_35), TYR_02, SCARB1_03, SLC23A1_05. CD80_04, BCL2L1_03, CASP9, EPHX1_15, and ERCC4_01 genes: See the blog entry Gene variations and diseases – far from simple.
PINK1 gene: See the blog entry Mitochondria and Parkinson’s Disease.
RAS2 and SCH9 genes: See the blog entry Life extension by a factor of 10.
APOE4 and TOMM40 genes: See the blog entry APOE4 gene variant, memory loss and Alzheimer’s Disease risk
Fas and FasL genes: See the blog entry: Fascinating dance of death and life – Fas, FasL and diseases. See also : Autoimmune diseases and lymphoma: Part I: focus on Lupus.
TREX1 gene: See the blog entry: Autoimmune diseases and lymphoma: Part I: focus on Lupus.
TNF superfamily of genes within chromosome 6p21.3 and Bcl-2 gene: See the blog entry: Autoimmune diseases and lymphoma – Part III: focus on lymphomas.
FTO gene: See the blog entry: The “skinny” about the “fatso” gene FTO.
FOXO genes: See the blog entry: FOXO genes and protecting stem cells — What does resveratrol do?
KLOTHO gene: See the blog entry: Klotho anti-aging gene in the news.
NRG1 gene: See the blog entry: The NRG1 Gene – an important new tumor suppressor gene? And press sensationalism about it.
BRCA1, BRCA2, APC, RB1. WIF1, MLH1, TIMP3, PTEN, APC, CD95, RASSF1A, E cadherin, RECK and GSTP1 genes: See the blog entry: DNA demethylation – a new way of coming at cancers.
Factor 5A1 gene: See the blog entry: Senesco and the Factor 5A1 gene.
RPE65 gene: See the blog entry: A gene therapy home run.
UCP1, PRDM16 genes: See the blog entry: Getting skinny from brown fat.