I read your new Micronutrient Triage Theory based on Ames work, nice write-up. I was also thinking about how networks are important – Packer’s work and also Bill Lands
http://efaeducation.nih.gov/sig/eicosa1.html

And also getting all the micronutrients within a family- e.g. toctrienols- appears to be important:
Chapter 12 on “Toctrienol Neuroprotection”
http://books.google.com/books?hl=en&lr=&id=ylX-GBKyLLkC&oi=fnd&pg=PP12&dq=lester+packer&ots=MeO3cTJCOB&sig=ZIc6xUjpkwodhYQRBMCpsWUdduY#v=onepage&q=&f=false

And now also the research of:
Part 2: Evolutionary Biologist Michael R. Rose, Ph.D. –
http://www.youtube.com/user/MaxLifeFoundation#p/u/9/SARG-G4lJRc

See slides beginning @7:10 where he points out that Cell biology/biochemistry has progressed from the view of Pathways (way outdated view) to Complex Networks (outdated view) to Vastly Complex Networks (current view) – which can probably include the Micronutrient Triage Theory. All 3 video parts are excellent, and he predicts that human healthspan can be doubled using nutriceuticals & pharmaceuticals based on genetics research.

The Micronutrient Triage Theory (Minimize DNA damage) may in the future be expanded/merged to include Maximizing the effect of longevity genes using nutriceuticals & pharmaceuticals based on Dr. Rose’s & others work (telomere lengthening). Need the research to determine which nutriceuticals & pharmaceuticals work on longevity genes, which seems to be coming.

Your aging theories are vastly complex interconnected networks.

Thanks for your blog, it will take a long time to catch up to you at your pace, keeps the mind working.

I have checked out all the citations you provided.

With respect to Vitamin C facilitating the reprogramming of cells to iPSC status, very interesting. Another thing to add to the already-long list of credentials of Vitamin C. There has been a lot of work during the last year on improving methods for reprogramming to get iPSCs with additional interesting results. I may generate a blog post on the topic.

As to Packer’s work and the work on micronutrients, also very good and classical stuff related to several of the theories of aging including Oxidative Damage and Mitochondrial Damage. I have covered much of this material including that related to Acetyl-l-carnitine and Alpha-lipoic acid in my treatise and, of course, in my suggested anti-aging supplement regimen and other blog posts.
Did you see my blog post on The micronutrient triage theory of aging? It is at http://anti-agingfirewalls.com/2009/12/05/the-micronutrient-triage-theory-of-aging/

Vince

Wow! Thanks for the links. I will look at them, see what other relevant stuff there is and get back with a substantive related comment before long.

Vince

There is also Packer’s work:
The Antioxidant Miracle: Your Complete Plan for Total Health and Healing, by Lester Packer and Carol Colman, 1999
http://www.ajcn.org/cgi/content/full/71/2/604
http://www.jbc.org/content/275/17/13049.full.pdf+html
http://www.ajcn.org/cgi/reprint/81/4/736
&
“Micronutrients and Brain Health” By Lester Packer, Helmut Sies, Manfred Eggersdorfer, Enrique Cadenas (2009)
http://books.google.com/books?hl=en&lr=&id=ylX-GBKyLLkC&oi=fnd&pg=PP12&dq=lester+packer&ots=MeO4eTMBLw&sig=H93lnqQ1LgHAbQYXG57f-BjOEx8#v=onepage&q=&f=false

and
http://lpi.oregonstate.edu/ss04/ageessential.html