Comments on: Exercise, telomerase and telomeres http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/ A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. Tue, 07 Feb 2012 16:23:41 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: michael83727 http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-56711 michael83727 Sun, 23 Oct 2011 15:43:23 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-56711 Hi, I do a combination of running (what you would call "vigorous"), lighter cardio (gym bike), and weight lifting. I am wondering what in your conclusion constitutes "very heavy weights". From reading elsewhere, and experience, I have found there to be a lot of health benefits from increased muscle mass. A higher resting metabolism, for one thing, helps to burn off calories and stay trim even when you are not on the trail. Stronger legs and back make running easier and should theoretically put less wear-and-tear on the bones, ligaments, cartilage, tendons. Also, I have read that growth hormone, which aids in tissue repair, is stimulated by weight lifting. So, I am wondering at what threshold the benefits of additional natural growth hormone production and higher muscle mass are outweighed by the negative side effects on the PBMC telomeres. For reference, I do approximately 60 minutes of cardio (130-140 HR bike, some hard sprints) and 30 minutes of weightlifting daily in the evenings, with an additional 5-6 mile run (155-180 HR) on sat/sun mornings. I am never really "wiped out" by any of my workouts, but I definitely try to lift to the point where my muscles are worked hard, and need rest to regain their strength. It's hard to define very heavy - compared to a sedentary office drone I can lift a lot, but I do not even bench press my own weight as a regular set. Hi,

I do a combination of running (what you would call “vigorous”), lighter cardio (gym bike), and weight lifting. I am wondering what in your conclusion constitutes “very heavy weights”.

From reading elsewhere, and experience, I have found there to be a lot of health benefits from increased muscle mass. A higher resting metabolism, for one thing, helps to burn off calories and stay trim even when you are not on the trail. Stronger legs and back make running easier and should theoretically put less wear-and-tear on the bones, ligaments, cartilage, tendons.

Also, I have read that growth hormone, which aids in tissue repair, is stimulated by weight lifting.

So, I am wondering at what threshold the benefits of additional natural growth hormone production and higher muscle mass are outweighed by the negative side effects on the PBMC telomeres. For reference, I do approximately 60 minutes of cardio (130-140 HR bike, some hard sprints) and 30 minutes of weightlifting daily in the evenings, with an additional 5-6 mile run (155-180 HR) on sat/sun mornings. I am never really “wiped out” by any of my workouts, but I definitely try to lift to the point where my muscles are worked hard, and need rest to regain their strength. It’s hard to define very heavy – compared to a sedentary office drone I can lift a lot, but I do not even bench press my own weight as a regular set.

]]> By: Telomerase Explained - A Must See Video | Anti Aging Nutrition News http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-56689 Telomerase Explained - A Must See Video | Anti Aging Nutrition News Thu, 06 Oct 2011 20:07:29 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-56689 [...] // #split {}#single {}#splitalign {margin-left: auto; margin-right: auto;}#singlealign {margin-left: auto; margin-right: auto;}.linkboxtext {line-height: 1.4em;}.linkboxcontainer {padding: 7px 7px 7px 7px;background-color:#eeeeee;border-color:#000000;border-width:0px; border-style:solid;}.linkboxdisplay {padding: 7px 7px 7px 7px;}.linkboxdisplay td {text-align: center;}.linkboxdisplay a:link {text-decoration: none;}.linkboxdisplay a:hover {text-decoration: underline;} function opensingledropdown() { document.getElementById('singletablelinks').style.display = ''; document.getElementById('singlemouse').style.display = 'none'; } function closesingledropdown() { document.getElementById('singletablelinks').style.display = 'none'; document.getElementById('singlemouse').style.display = ''; } Myths and facts about telomeres and telomerase activationElizabeth Blackburn Part 1 The Roles of Telomeres and TelomeraseAging: Telomeres And TelomeraseTelomeres and Telomerase – The New Buzz Words in Anti-Aging?Exercise, telomerase and telomeres [...] [...] // #split {}#single {}#splitalign {margin-left: auto; margin-right: auto;}#singlealign {margin-left: auto; margin-right: auto;}.linkboxtext {line-height: 1.4em;}.linkboxcontainer {padding: 7px 7px 7px 7px;background-color:#eeeeee;border-color:#000000;border-width:0px; border-style:solid;}.linkboxdisplay {padding: 7px 7px 7px 7px;}.linkboxdisplay td {text-align: center;}.linkboxdisplay a:link {text-decoration: none;}.linkboxdisplay a:hover {text-decoration: underline;} function opensingledropdown() { document.getElementById('singletablelinks').style.display = ''; document.getElementById('singlemouse').style.display = 'none'; } function closesingledropdown() { document.getElementById('singletablelinks').style.display = 'none'; document.getElementById('singlemouse').style.display = ''; } Myths and facts about telomeres and telomerase activationElizabeth Blackburn Part 1 The Roles of Telomeres and TelomeraseAging: Telomeres And TelomeraseTelomeres and Telomerase – The New Buzz Words in Anti-Aging?Exercise, telomerase and telomeres [...]

]]> By: PGC-1alpha and exercise | AGING SCIENCES – Anti-Aging Firewalls http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-56621 PGC-1alpha and exercise | AGING SCIENCES – Anti-Aging Firewalls Thu, 11 Aug 2011 20:14:18 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-56621 [...] and biological mechanisms that produce those health and longevity effects.  See the blog entries Exercise, telomerase and telomeres, and On the conventional wisdom of [...] [...] and biological mechanisms that produce those health and longevity effects.  See the blog entries Exercise, telomerase and telomeres, and On the conventional wisdom of [...]

]]> By: russische frau http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-55346 russische frau Mon, 30 May 2011 10:23:14 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-55346 I am interested in it for a long time! For example, perhaps the benefits of certain water soluble vitamins such as vitamin C (I take 4g per day) may be diminished if I need to drink extra water and expend it in the an increased volume of urine and/or sweat. I am interested in it for a long time! For example, perhaps the benefits of certain water soluble vitamins such as vitamin C (I take 4g per day) may be diminished if I need to drink extra water and expend it in the an increased volume of urine and/or sweat.

]]> By: admin http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-7633 admin Tue, 30 Mar 2010 21:43:25 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-7633 Philip Terry: Thanks for the interesting links. I must confess that I have never dug deeply into biomarkers and that is something I should definitely do. I am starting by ordering the book, a bargain used from the Amazon sellers listed. Vince Philip Terry:
Thanks for the interesting links. I must confess that I have never dug deeply into biomarkers and that is something I should definitely do. I am starting by ordering the book, a bargain used from the Amazon sellers listed.
Vince

]]> By: Philip Terry http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-7569 Philip Terry Mon, 29 Mar 2010 21:40:59 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-7569 I got hooked on the concept of "10 biomarkers of vitality" muscle mass seems to positively influence all of them - someone mentioned that running had some negatives... http://www.cbass.com/Biomarkers.htm http://www.amazon.com/Biomarkers-Evans/dp/0130875783 I got hooked on the concept of “10 biomarkers of vitality” muscle mass seems to positively influence all of them – someone mentioned that running had some negatives… http://www.cbass.com/Biomarkers.htm

http://www.amazon.com/Biomarkers-Evans/dp/0130875783

]]> By: admin http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5804 admin Wed, 20 Jan 2010 16:47:46 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5804 Singularityfan: Iwill have a look. Vince Singularityfan:

Iwill have a look.
Vince

]]> By: singularityFan http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5801 singularityFan Tue, 19 Jan 2010 20:41:52 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5801 Vince, Not sure if you know about this website, but it compiles new research from leading universities. http://futurity.org/category/health-medicine/ - singularityFan Vince,

Not sure if you know about this website, but it compiles new research from leading universities.

http://futurity.org/category/health-medicine/

- singularityFan

]]> By: admin http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5785 admin Sun, 17 Jan 2010 18:32:06 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5785 Jeg3: Your comment has got me going. It appears that a number of research publications are reporting on beta-alanine for maintaining muscle carnosine and muscle strength both in atheletes and in the elderly. Could well be an important topic for both young and old. Also, there appears to be a fascinating set of similarities in behavior of beta-alanine, l-carnosine and Gabapentin in terms of actions on GABA receptors in nerves and glia. I am currently working on a blog post on the first topic and may also do one on the second topic which is both fascinating and complex. Relates to topics like pain management, maintaining mental balance, sleep and mental acuity. Thanks for playing this game with me. Vince Jeg3:

Your comment has got me going. It appears that a number of research publications are reporting on beta-alanine for maintaining muscle carnosine and muscle strength both in atheletes and in the elderly. Could well be an important topic for both young and old. Also, there appears to be a fascinating set of similarities in behavior of beta-alanine, l-carnosine and Gabapentin in terms of actions on GABA receptors in nerves and glia. I am currently working on a blog post on the first topic and may also do one on the second topic which is both fascinating and complex. Relates to topics like pain management, maintaining mental balance, sleep and mental acuity.

Thanks for playing this game with me.

Vince

]]> By: admin http://www.anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5781 admin Sun, 17 Jan 2010 04:29:32 +0000 http://anti-agingfirewalls.com/2010/01/14/exercise-telomerase-and-telomeres/#comment-5781 <p>Jeg3:</p> <p>Regarding beta-alanine, I have not paid too much attention to it up to now for I have been mainly thinking of it as a precursor to carnosine and I have been doing direct supplementation with l-carnosine for something like 12 years now. It is an incredible substance. See my blog post The Curious Case of l-Carnosine at http://anti-agingfirewalls.com/2009/11/30/the-curious-case-of-l-carnosine/. I fell in love with carnosine when I learned about its ability to expand the replicative lifespan of fibroblasts by a factor of 3 and still think it is an incredible substance.</p> <p>However, it may well be the case that the bioavailability of<br /> beta-alanine makes it a better substance for building carnosine levels in muscles. I am going to have a hard look at your references and this issue, and will get back to you either here in another comment or in a new blog post.</p> <p>Vince</p> Jeg3:

Regarding beta-alanine, I have not paid too much attention to it up to now for I have been mainly thinking of it as a precursor to carnosine and I have been doing direct supplementation with l-carnosine for something like 12 years now. It is an incredible substance. See my blog post The Curious Case of l-Carnosine at http://anti-agingfirewalls.com/2009/11/30/the-curious-case-of-l-carnosine/. I fell in love with carnosine when I learned about its ability to expand the replicative lifespan of fibroblasts by a factor of 3 and still think it is an incredible substance.

However, it may well be the case that the bioavailability of
beta-alanine makes it a better substance for building carnosine levels in muscles. I am going to have a hard look at your references and this issue, and will get back to you either here in another comment or in a new blog post.

Vince

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