Comments on: Vitamins, supplements and telomerase – upregulation or downregulation? http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/ A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. Wed, 08 Feb 2012 23:01:00 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: Wellness http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-56544 Wellness Mon, 27 Jun 2011 21:11:46 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-56544 FYI Vince, P16: http://www.sciencedaily.com/releases/2011/04/110405082616.htm FYI Vince, P16:
http://www.sciencedaily.com/releases/2011/04/110405082616.htm

]]> By: Wellness http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-56525 Wellness Tue, 14 Jun 2011 17:13:00 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-56525 New Clues About Aging: Genetic Splicing Mechanism Triggers Both Premature Aging Syndrome and Normal Cellular Aging: http://www.sciencedaily.com/releases/2011/06/110613121956.htm New Clues About Aging: Genetic Splicing Mechanism Triggers Both Premature Aging Syndrome and Normal Cellular Aging:
http://www.sciencedaily.com/releases/2011/06/110613121956.htm

]]> By: andrew http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-51319 andrew Tue, 10 May 2011 05:43:09 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-51319 Hi Vince. I've always considered carnosine one of the "benign guys" in my supplement arsenal, a non-toxic sweetheart. I just read a disturbing piece of information that has me re-thinking whether or not I should continue using carnosine(1000mg daily). What are your thoughts on the neurotoxic condition known as carnosinemia? Is there trouble in paradise for those of us who supplement w/ carnosine? http://metabolicresearch.org/10001/20401.html Hi Vince.
I’ve always considered carnosine one of the “benign guys” in my supplement arsenal, a non-toxic sweetheart.

I just read a disturbing piece of information that has me re-thinking whether or not I should continue using carnosine(1000mg daily).

What are your thoughts on the neurotoxic condition known as carnosinemia? Is there trouble in paradise for those of us who supplement w/ carnosine?

http://metabolicresearch.org/10001/20401.html

]]> By: Alma H. Bond, Ph.D. http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-49397 Alma H. Bond, Ph.D. Mon, 25 Apr 2011 00:59:09 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-49397 I am a psychoanalyst and much published author who is currently planning to write a book on life extension. I am interested in interviewing people who have taken TA-65. If you are such a person and would like to be interviewed, please contact me at almahb@aol.com. Thank you, Alma H. Bond, Ph.D. I am a psychoanalyst and much published author who is currently planning to write a book on life extension. I am interested in interviewing people who have taken TA-65. If you are such a person and would like to be interviewed, please contact me at almahb@aol.com. Thank you,
Alma H. Bond, Ph.D.

]]> By: Vincent Giuliano http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-48558 Vincent Giuliano Sat, 16 Apr 2011 18:03:14 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-48558 Andrew: Regarding your questions: Dear Vince, I read your revised nutritional supplementation list. I was wondering: 1. Does your b-complex contain nicatinomide or niacinamide? I know that you’ve frowned on these two b-complex constituents in the past. What brand of b-complex do you use? Yes. It is almost impossible to find a B-complex supplement that does not contain a small amount of one or tje other, I have been somewhat promiscious with regard to shopping for B-complex pills, trying for a supplement that does not drive me over 900mcg of folic acid if I take it twice a day. 2. Do you take a multi vitamin? If so what brand? I do not. 3. Have you considered re-introducing NAC into your regimen? Recent studides indicate that NAC does not cause mycardial infarction. I have not used it regularly but have a bottle of it and use it if and when I feel need a slug of extra-powerful antioxidant. I would use if, for example, if I ever had to have a CAT-scan ( which I avoid when possible) or if I knew I were exposed to some toxic metal. 4. Is SAMe on your radar? It supportst brain, joint and liver health… I’m sure you could write a thesis on the subject! It is on my radar and I have encouraged my wife to take it in the past. Goog suggestion! Don't know when I can get to it since I have a very full plate now Vince Andrew:

Regarding your questions:
Dear Vince,

I read your revised nutritional supplementation list.

I was wondering:

1. Does your b-complex contain nicatinomide or niacinamide? I know that you’ve frowned on these two b-complex constituents in the past. What brand of b-complex do you use?

Yes. It is almost impossible to find a B-complex supplement that does not contain a small amount of one or tje other, I have been somewhat promiscious with regard to shopping for B-complex pills, trying for a supplement that does not drive me over 900mcg of folic acid if I take it twice a day.

2. Do you take a multi vitamin? If so what brand?

I do not.

3. Have you considered re-introducing NAC into your regimen? Recent studides indicate that NAC does not cause mycardial infarction.

I have not used it regularly but have a bottle of it and use it if and when I feel need a slug of extra-powerful antioxidant. I would use if, for example, if I ever had to have a CAT-scan ( which I avoid when possible) or if I knew I were exposed to some toxic metal.

4. Is SAMe on your radar? It supportst brain, joint and liver health… I’m sure you could write a thesis on the subject!

It is on my radar and I have encouraged my wife to take it in the past. Goog suggestion! Don’t know when I can get to it since I have a very full plate now

Vince

]]> By: andrew http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-48509 andrew Sat, 16 Apr 2011 02:07:12 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-48509 Dear Vince, I read your revised nutritional supplementation list. I was wondering: 1. Does your b-complex contain nicatinomide or niacinamide? I know that you've frowned on these two b-complex constituents in the past. What brand of b-complex do you use? 2. Do you take a multi vitamin? If so what brand? 3. Have you considered re-introducing NAC into your regimen? Recent studides indicate that NAC does not cause mycardial infarction. 4. Is SAMe on your radar? It supportst brain, joint and liver health... I'm sure you could write a thesis on the subject! Dear Vince,

I read your revised nutritional supplementation list.

I was wondering:

1. Does your b-complex contain nicatinomide or niacinamide? I know that you’ve frowned on these two b-complex constituents in the past. What brand of b-complex do you use?

2. Do you take a multi vitamin? If so what brand?

3. Have you considered re-introducing NAC into your regimen? Recent studides indicate that NAC does not cause mycardial infarction.

4. Is SAMe on your radar? It supportst brain, joint and liver health… I’m sure you could write a thesis on the subject!

]]> By: admin http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-37593 admin Wed, 19 Jan 2011 22:47:56 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-37593 Kevin For their presumed telomerase-activating effects, I took astragaloside IV for nearly two years and then a low dose of cycloastragenol (5mg a day) for nearly a year but, except for occasional use, have discontinued taking these supplements. My reasons are several: 1. It is unclear to me in terms of published results that there is a clear health benefit to taking these substances. Many other factors impact on telomere lengths and it appears that the impact of taking cycloastragenol is relatively weak in health individuals. For people with certain deficiencies such as T-cell senescence brought on by HIV or cytomegalovirus, it is likely to be more valuable. Have you seen the publication at http://www.ncbi.nlm.nih.gov/pubmed ? 2. I have over the last two years learned a lot more about cell senescence and its causes and see short telomeres more as a symptom of other senescence-promoting causes than itself as a driving factor for cell senescence, or for aging itself. 3. The health-producing effects of a great many of the other supplements I take are well-established in the published literature and I do not want to give them up for days at a time for the relatively unproven benefits of taking cycloastragenol. 4. On careful consideration, it is unclear that taking the substance provided me with any health benefits, though it could have. 5. If I had an inexpensive source of pharmaceutical-grade cycloastragenol and its benefits did not require not taking other supplements, I would probably be still taking it. As matters stand, it does not appear worthwhile for me to do so. Has the cycloastragenol you are taking been tested to make sure it is free of impurities like heavy metals? Vince Kevin

For their presumed telomerase-activating effects, I took astragaloside IV for nearly two years and then a low dose of cycloastragenol (5mg a day) for nearly a year but, except for occasional use, have discontinued taking these supplements. My reasons are several:

1. It is unclear to me in terms of published results that there is a clear health benefit to taking these substances. Many other factors impact on telomere lengths and it appears that the impact of taking cycloastragenol is relatively weak in health individuals. For people with certain deficiencies such as T-cell senescence brought on by HIV or cytomegalovirus, it is likely to be more valuable. Have you seen the publication at http://www.ncbi.nlm.nih.gov/pubmed ?

2. I have over the last two years learned a lot more about cell senescence and its causes and see short telomeres more as a symptom of other senescence-promoting causes than itself as a driving factor for cell senescence, or for aging itself.

3. The health-producing effects of a great many of the other supplements I take are well-established in the published literature and I do not want to give them up for days at a time for the relatively unproven benefits of taking cycloastragenol.

4. On careful consideration, it is unclear that taking the substance provided me with any health benefits, though it could have.

5. If I had an inexpensive source of pharmaceutical-grade cycloastragenol and its benefits did not require not taking other supplements, I would probably be still taking it. As matters stand, it does not appear worthwhile for me to do so.

Has the cycloastragenol you are taking been tested to make sure it is free of impurities like heavy metals?

Vince

]]> By: admin http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-37588 admin Wed, 19 Jan 2011 21:52:01 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-37588 Steve Your point about the superior bioactibvity of R-ALA is well-taken. Thanks Vince Steve

Your point about the superior bioactibvity of R-ALA is well-taken.

Thanks
Vince

]]> By: Steve http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-37447 Steve Tue, 18 Jan 2011 19:01:33 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-37447 Noticed at the top of the page, even though it's old, some talk about ALA. Just wanted to add, if anyone's taking an ALA supplement that the R-ALA has shown to be several times more effective than just ALA (R-ALA + S-ALA) and is no more expensive. It is like the difference between CoQ10 and Ubiquinol, the latter is the biologically active form and the one more easily utilized by the body. Lots of great telomere information here, thanks for your site I will definitely bookmark it. Noticed at the top of the page, even though it’s old, some talk about ALA. Just wanted to add, if anyone’s taking an ALA supplement that the R-ALA has shown to be several times more effective than just ALA (R-ALA + S-ALA) and is no more expensive. It is like the difference between CoQ10 and Ubiquinol, the latter is the biologically active form and the one more easily utilized by the body.

Lots of great telomere information here, thanks for your site I will definitely bookmark it.

]]> By: Kevin http://www.anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-35895 Kevin Thu, 06 Jan 2011 04:17:12 +0000 http://anti-agingfirewalls.com/2010/01/22/vitamins-supplements-and-telomerase-%e2%80%93-upregulation-or-downregulation/#comment-35895 You all were taking Cycloastragenol for over an year now. Did you see any side effects? Revgenetics recommend to take Cycloastragenol for 15 days and then 15 days break.I am taking 2 capsules(5mg) for almost a month now. I feel much better with energy and my skin is getting better. I am 40. I bought Cycloastragenol recently from BiologixPeptide.com. They are $88 for 2 months supply but it says for lab use only. How long should I take Cycloastragenol? How much off period is recommended? I appreciate your guidance and help. Thanks Kevin You all were taking Cycloastragenol for over an year now.
Did you see any side effects?
Revgenetics recommend to take Cycloastragenol for 15 days and then 15 days break.I am taking 2 capsules(5mg) for almost a month now. I feel much better with energy and my skin is getting better. I am 40. I bought Cycloastragenol recently from BiologixPeptide.com. They are $88 for 2 months supply but it says for lab use only. How long should I take Cycloastragenol?
How much off period is recommended?
I appreciate your guidance and help.

Thanks
Kevin

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