This blog is now a year old and represents an accumulation of 232 posts and 270 comments. My favorite thing seems to be reporting recent research findings in context, providing discussion and a network of citations for understanding how newly-reported research fits in to what is already known. This has required much thinking on my part and many ideas that are original to me have appeared here. But there also have been two streams of brand-new original thinking that have appeared in this blog, ideas that did not exist “out there” before they appeared here. The purpose of this post is to highlight those two streams and point to the posts that contain them.
The first stream relates to Giuliano’s Law, which is “Starting now, every seven years will see the emergence of practical age-extension interventions (ones that have a potential of leading to extraordinary longevity) that double the power of the interventions available at the start of the 7 year period. That is, on an average basis, the practical anti-aging interventions available at the end of a seven-year period will enable twice the number of years of life extension than did the interventions available at the start of the period. Life extension is measured in years of life expectancy beyond those actuarially predicted for a given population.
This law and some of the rationale for it was laid out in the March 2009 post Giuliano’s Law: Prospects for breaking through the 122 year human age limit. It is an analog of Moore’s law for the power of computers and is valid for many of the same reasons. The post Factors that drive Giuliano’s Law goes into those reasons in detail, a positive feedback loop of interaction exists between societal need, market, marketing channels and economics, changes in user expectations, market vehicles, user applications, marketing channels, advancement in the relevant basic science, advancement in technology, advancement in manufacturing, and entrepreneurial environment.
I argue that the juggernaut defined by these interacting factors is already immense, growing mightily in power and on the road just as surely as the computer revolution was on the road in 1958. The same advances that further health and medicine will further the cause of longevity. Anti-aging science is not some arcane discipline off to the side. It is a natural byproduct of the life sciences revolution that is well underway.
The blog post More on Giuliano’s Law; calculating my longevity prospects is a more personal one, looking at my own life expectancy assuming Giuliano’s law is correct under three scenarios: Case 1: I discontinue my anti-aging firewalls program and go about living a normal life. Case 2: I continue pursuing my existing anti-aging firewall program keeping it exactly as it is now and Case 3: I continue to follow all the relevant threads of anti-aging research, to update the Anti-Aging Firewalls Treatise weekly or more as I have been doing, and periodically update the firewalls and firewall program to reflect this emerging new knowledge. Further, I incorporate new science-based anti-aging substances and procedures into the firewall program as they become available. As you might guess, the Case 3 projection is that I have a good shot at breaking the 123 years maximum age barrier. I hope that I am right!
The stem cell supply chain theory of aging
After generating a number of blog posts related to stem cells and stem cell differentiation I started to see a whole new viewpoint on aging connected with stem cells. I first laid this viewpoint out in my September 2009 blog post An emerging new view of aging – the stem cell supply chain. The idea is that there is a hierarchy of stem cells in human bodies ranging from pluripotent embryonic-like stem cells at the top to specialized progenitor cells just above ordinary somatic cells, with senescent cells at the very bottom of the heap. In a healthy living organism, a supply chain is in constant operation. Cells at one level are replenished by differentiation of cells at a higher level. In aging the pools of stem cells at the higher levels become exhausted, cell regeneration via differentiation of stem cells is compromised, and sickness and death follow.
The blog entry The stem cell supply chain – closing the loop for very long lives suggests an approach that could conceivably transform the stem cell supply chain from being a once-through process to being a continuous loop. The idea is to generate autologous induced pluripotent stem cells in order to keep the stem cell supply chain operating indefinitely. I have created a large number of posts about stem cells and the stem cell supply chain is an underlying concept of several of them.
A follow-up posting will comment on how my views of aging and anti-aging interventions have evolved since starting this blog.