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The press has been making a big deal of research made public a few days ago that correlates a genetic defect in one of the key telomerase-producing genes TERC with shorter telomeres later in life. This link leads to 23 news stories on the research. The abstract of the study itself Common variants near TERC are associated with mean telomere lengthreads succinctly:“We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.“This sitegraphically shows key data produced by the study.
The study says that people who possessed the gene variation (minor allele of rs12696304) had shorter telomere lengths, equivalent to 3.6 years of aging.People who had two copies of the variation had telomere lengths expected for people 7.2 years older.The implication is that people with the gene defect age faster.I think the study is a good piece of research to add to the aging puzzle but that it is not the big-deal breakthrough suggested in the news headlines because:
The idea raised by this study of people aging at variable rates depending on their genes is an interesting and probably valid one though definitely not new. Children born with a mutation in the LMNA gene look old and wizened and are experiencing the ravaging diseases of old age when they are only 14 or 15. See the blog entry Progerin, HGPS and a possible new theory of aging.Personally, I believe lifestyle and behavioral factors affect the rate of aging along with the genetic ones.That is the point of the lifestyle and dietary supplements regimens suggested in my treatise ANTI-AGING FIREWALLS THE SCIENCE AND TECHNOLOGY OF LONGEVITY.
About Vince Giuliano
Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com.
Please note that I have recently changed my mailbox to firstname.lastname@example.org.