Monthly Archives: April 2010

In the recent blog post Harnessing the engines of finance and commerce for life-extension, I characterized a new approach to health, medicine and  longevity called Personalized Predictive Preventative Participatory Medicine (PPPPM). I also promised to describe specific examples in subsequent blog … Continue reading →

On several occasions both in this blog and in my treatise I have pointed out the need for integrating the various disparate theories of aging into an overall systems framework.  Following is the abstract for a presentation I will be … Continue reading →

Suppose I reported that billions of dollars will be spent on life-extension research next year and that soon that number will reach tens of billions?  The first reaction of aging-science researchers would be “no way.”  They would point to the … Continue reading →

I am out attending the Bio-IT World Conference & Expo in Boston a good part of this week, paying particular attention to the track on Systems and Predictive Technology.  The conference is focused on a fundamental shift happening in biological and medical research, … Continue reading →

Don’t let the fancy name scare you off.  The underlying concepts are fairly simple.  The basic idea is to go after cancer cells with viruses that kill them.  To help the viruses escape the immune system, they are packaged in … Continue reading →

Perhaps the two most comprehensive theories explaining aging in my treatise are Programmed Epigenomic Changes and Stem Cell Supply Chain Breakdown.  Recent research related to the epigenetics of stem cells deals with the profound underlying relationships between those two theories.  … Continue reading →

DNA repair is a major defense against the second cause of aging described in my treatise Cell DNA Damage.  Such repair is absolutely necessary. Damage can be caused by oxidative processes, radiation exposure, and exposure to environmental toxins, cigarette smoke … Continue reading →

Up until a couple of months ago, the answer seemed very clear to me.  Resveratrol offers a number of powerful health-promoting effects.  Also, it turns on the SIRT1 gene activating the same evolutionary-conserved pathway that is known to confer longevity … Continue reading →

Astragalus-based dietary supplements that are known to activate the expression of telomerase have been on the market for several years now.  However, there appears to be a significant difference between what these supplements are widely publicized to do and what … Continue reading →

I have reported on Induced pluripotent stem cells (iPSCs) in my treatise and in numerous past blog entries(ref)(ref)(ref).  I have viewed these cells as probably providing  the golden keys to closing the loop on the stem cell supply chain allowing … Continue reading →