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In a study published May 8 in the open-access journal PLoS Genetics, researchers from the University of Southern California Andrus Gerontology Center show that yeast cells maintained on a glycerol diet live twice as long as normal — as long as yeast cells on a severe caloric-restriction diet. They are also more resistant to cell damage.

Many studies have shown that caloric restriction can extend the life span of a variety of laboratory animals. Caloric restriction is also known to cause major improvements in a number of markers for cardiovascular diseases in humans. This study is the first to propose that “dietary substitution” can replace “dietary restriction” in a living species.

“If you add glycerol, or restrict caloric intake, you obtain the same effect,” said senior author Valter Longo. “It’s as good as calorie restriction, yet cells can take it up and utilize it to generate energy or for the synthesis of cellular components.”

Longo and colleagues Min Wei and Paola Fabrizio introduced a glycerol diet after discovering that genetically engineered long-lived yeast cells that survive up to 5-fold longer than normal have increased levels of the genes that produce glycerol. In fact, they convert virtually all the glucose and ethanol into glycerol. Notably, these cells have a reduced activity in the TOR1/SCH9 pathway, which is also believed to extend life span in organisms ranging from worms to mice.

When the researchers blocked the genes that produce glycerol, the cells lost most of their life span advantage. However, Longo and colleagues believe that the “glucose to glycerol” switch represents only a component of the protective systems required for the extended survival. The current study indicates that glycerol biosynthesis is an important process in the metabolic switch that allows this simple organism to activate its protective systems and live longer.

“This is a fundamental observation in a very simple system,” Longo said, “that at least introduces the possibility that you don’t have to be calorie-restricted to achieve some of the remarkable protective effects of the hypocaloric diet observed in many organisms, including humans. It may be sufficient to substitute the carbon source and possibly other macronutrients with nutrients that do not promote the “pro-aging” changes induced by sugars.”

Funding for the study came from the American Federation for Aging Research and the National Institute on Aging (NIH).

Yes, my daily exercise often consists of brisk walks in the woods surrounding my house or on the treadmill while I watch a movie.
Vince

Sorry, I disagree. First of all, despite many years of hope, there is no evidence that telomere-elongation increases human lifespan though it may have other positive health effects. I have researched and written very extensively about this as you can see by searching in this blog or checking out my treatise at http://www.vincegiuliano.name/Antiagingfirewalls.htm. Show me one experiment where telomere elongation has extended the lives of normal mice or other mammals. I can show you hundreds of papers where other interventions have extended such lives.

Second, I believe that while HGH supplementation or promotion may provide temporary strength benefits it is discredited as a life-extension strategy and may in fact shorten life. See http://www.hopkinsmedicine.org/Press_releases/2010/01_26a_10.html and http://ajp.amjpathol.org/cgi/content/full/160/6/2259

I suggest that the place to look for valid information is in the aresponsible research literature and that statements in commercial sites that sell anti-aging supplements or services need to be checked out carefully.
Vince

Throughout history mankind has had a burning desire to find ways to add to the length of their lifespan.

There are many foods and activities that have been shown to maximize the length of ones life depending upon the inherent genetic composition of ones heritage.

The telomere theory of life span indicates every time a cell dies and a new cell splits, the length of the telomere is shortened. Once the cell has become too short, the cell no longer can divide into two new cells. Human growth hormone has been shown to have the capability of elongating the telomere and as such, if the theory is correct, is a basic ingredient in adding to one’s lifespan. For more of a history on HGH come to our website at Stop Age.