http://www.anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/ A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. Tue, 07 Feb 2012 16:23:41 +0000 hourly 1 http://wordpress.org/?v=3.2.1 http://www.anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/#comment-63052 Dietary factors and dementia Part 2: possible interventions | AGING SCIENCES – Anti-Aging Firewalls Wed, 11 Jan 2012 19:25:39 +0000 http://anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/#comment-63052 [...] (UPR) which, in aging, combats endoplasmic reticulum (ER) stress.  Also see the blog entry HSP70 to the rescue.  There, I pointed out that the hormetic responses of HSP70 in humans may be evoked by exercise, [...] [...] (UPR) which, in aging, combats endoplasmic reticulum (ER) stress.  Also see the blog entry HSP70 to the rescue.  There, I pointed out that the hormetic responses of HSP70 in humans may be evoked by exercise, [...]

]]> http://www.anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/#comment-56605 Age-related cognitive decline: focus on interventions | AGING SCIENCES – Anti-Aging Firewalls Wed, 27 Jul 2011 21:58:29 +0000 http://anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/#comment-56605 [...] The unfolded protein response (UPR) appears to be a response to sleep-deprivation stress.  The 2009 publication Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders reports “Recent transcript profiling and microarray studies are beginning to unveil some of the mysteries of sleep. One of the most important clues has been the identification of the endoplasmic reticulum (ER) resident chaperone, immunoglobulin binding protein (BiP), that increases with sleep deprivation in all species studied. BiP, an ER resident chaperone, is the key cellular marker and master regulator of a signaling pathway called the ER stress response or unfolded protein response. The ER stress response occurs in 3 phases. It is healthy, protective and adaptive when the ER stress is moderate. Failure of the adaptive response leads to the activation of an inflammatory response. When the ER stress burden is great and prolonged, executioner pathways are activated. Collectively this work provides new evidence that modest sleep deprivation induces cellular stress that activates an adaptive response. Aging tilts the response to sleep deprivation from one that is adaptive and protective to one that is maladaptive. Understanding the pathways activated by sleep loss and the mechanisms by which they occur will allow the development of therapies to protect the brain during prolonged wakefulness and specifically in sleep disorders including those associated with aging.”  The unfolded protein response (UPR) is discussed in the blog entry HSP70 to the rescue. [...] [...] The unfolded protein response (UPR) appears to be a response to sleep-deprivation stress.  The 2009 publication Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders reports “Recent transcript profiling and microarray studies are beginning to unveil some of the mysteries of sleep. One of the most important clues has been the identification of the endoplasmic reticulum (ER) resident chaperone, immunoglobulin binding protein (BiP), that increases with sleep deprivation in all species studied. BiP, an ER resident chaperone, is the key cellular marker and master regulator of a signaling pathway called the ER stress response or unfolded protein response. The ER stress response occurs in 3 phases. It is healthy, protective and adaptive when the ER stress is moderate. Failure of the adaptive response leads to the activation of an inflammatory response. When the ER stress burden is great and prolonged, executioner pathways are activated. Collectively this work provides new evidence that modest sleep deprivation induces cellular stress that activates an adaptive response. Aging tilts the response to sleep deprivation from one that is adaptive and protective to one that is maladaptive. Understanding the pathways activated by sleep loss and the mechanisms by which they occur will allow the development of therapies to protect the brain during prolonged wakefulness and specifically in sleep disorders including those associated with aging.”  The unfolded protein response (UPR) is discussed in the blog entry HSP70 to the rescue. [...]

]]> http://www.anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/#comment-56579 Alzheimer’s Disease Update – March 2011 | AGING SCIENCES – Anti-Aging Firewalls Thu, 14 Jul 2011 20:08:54 +0000 http://anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/#comment-56579 [...] [...] [...] [...]

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