Author Archives: James Watson

About James Watson

I am a physician with a keen interest in the molecular biology of aging. I have specific interests in the theories of antagonistic pleiotropy and hormesis as frameworks to understand cellular senescence and mechanisms for coping with cellular stress. The hormetic "stressors" that I am interested in exploiting at low doses include exercise, hypoxia, intermittent caloric restriction, radiation, etc. I also have a very strong interest in the epigenetic theory of aging and pharmacologic/dietary maintenance of histone acetylation and DNA methylation with age. I also am working on pharmacologic methods to destroy senescent cells and to reactivate quiescent endogenous stem cells. In cases where there is a "stem cell exhaustion" in the specific niche, I am very interested in stem cell therapy (Ex: OA)

Part 2 of interventions that reduce all cause mortality (ACM) – Metformin

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by James P Watson and Vince Giuliano There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably … Continue reading

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Inflammation Part 4 – PCSK9 inhibition – Also Part 1 of interventions that reduce all cause mortality (ACM)

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By James P Watson with inputs and editorial assistance by Vince Giuliano I.  INTRODUCTION This is the fourth in what we expect will be seven or more blog posts concerned with chronic inflammation.  It relates to a recently discovered protein … Continue reading

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Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions: 1)Inflammation, 2)Genomic Instability (p53), and 3)Oxidative stress (Nrf2)

By James Watson, with contributions and editing by Vince Giuliano We promised a major series of blog entries related to inflammation back in May 2016.    We said we would do that through narrating a number of inter-related stories many of … Continue reading

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Aging, health and disease – view from the DNA Methylome

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By James P. Watson with contributions and editing by Vince Giuliano Introduction (By Vince Giuliano) Jim Watson and I have held that aging and biology, like the universe itself, have no centers.  Like the universe, they can be looked at … Continue reading

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Part 5 of the NAD world: the conflicting roles of NAMPT – inflammation or rescue? Also Part 1 on a new series on inflammation

By James P Watson with commentary and assistance by Vince Giuliano Introduction by Vince Giuliano This blog entry relates another important story of what goes on in the NAD world. This is also the first entry of what I expect … Continue reading

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Hutchinson-Gilford Progeria Syndrome – a disease of accelerated aging due to Alternative Splicing

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By James P Watson with editorial assistance and contributions from Vince Giuliano I.  WHY YOU SHOULD BE INTERESTED IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) Summary: HGPS is a major clue to solving the “puzzle of aging” and the molecular mechanisms here … Continue reading

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Transposable DNA elements –- Part 2: The Self-copy Machines in Your Genes

By James P Watson with editorial and some content contribution by Vince Giuliano This is the second blog entry in a three-part series concerned with transposable DNA entries (TEs).  The Part 1 entry focused on basics of what TEs are, … Continue reading

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G-qaudruplexes

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By James P Watson with editorial help and selected contributions by Vince Giuliano Image source Human telomeric G-quadruplex structure  Introduction by Vince Giuliano If you are new to G-quadraplexes, I can appreciate reader resistance to confronting the intellectual challenge of … Continue reading

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The top 21Benefits of Meditation

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By James P Watson, with editorial assistance and comments by Vince Giuliano and Melody Winnig Initial  comments – by Vince Giuliano This blog entry is about thoroughly documented health and possible longevity benefits of meditation, quite apart from possible spiritual … Continue reading

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Part 4 of the NAD world: the NQ01 gene, the Warburg effect, SIRT 1 and inflammation, and possible interventions

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By James P Watson with contributions and editorial assistance by Vince Giuliano This Part 4 blog entry goes even further into the extended NAD story, examining important subtopics: The ratio NAD+/NADH in cells and the body, which may be as … Continue reading

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