About James Watson
I am a physician with a keen interest in the molecular biology of aging. I have specific interests in the theories of antagonistic pleiotropy and hormesis as frameworks to understand cellular senescence and mechanisms for coping with cellular stress. The
hormetic "stressors" that I am interested in exploiting at low doses include exercise, hypoxia, intermittent caloric restriction, radiation, etc. I also have a very strong interest in the epigenetic theory of aging and pharmacologic/dietary maintenance of histone acetylation and DNA methylation with age. I also am working on pharmacologic methods to destroy senescent cells and to reactivate quiescent endogenous stem cells. In cases where there is a "stem cell exhaustion" in the specific niche, I am very interested in stem cell therapy (Ex: OA)
This gallery contains 21 photos.
By James P Watson, with editorial assist, a little rounding out and a few comments by Vince Giuliano Image source I am convinced that actions in the Renin-Angiotensin cascade can be a major cause of inflammation, aging, and cancer. Exogenous antioxidants, … Continue reading →
This gallery contains 6 photos.
By James P. Watson, with help and some additions by Vince Giuliano Introduction Nuts have long been “labeled” as a bad source of nutrition due to their high fat content. However, a growing body of scientific studies have shown that … Continue reading →
This gallery contains 16 photos.
By James P Watson with assistance by Vince Giuliano This blog entry looks at the genetic and epigenetic factors in cancer. The news here is basically good – epigenetic transformations seem in many cases to be upstream of genetic mutations … Continue reading →
This gallery contains 22 photos.
By James P Watson with contributions and editing by Vince Giuliano This blog entry tells two stories. The first story is that of circular RNAs. Once we thought that any important DNA was located in the nucleus of cells on … Continue reading →
This gallery contains 2 photos.
By James P Watson I believe the the message of the previous blog entry Health through stressing fruits and vegetables – the Xenohormetic Live Food Hypothesis by Vince and Melody is worthy of acclaim. As so frequently happens, it fueled … Continue reading →
This gallery contains 27 photos.
A collection of stories and explanations by Jim Watson and Vince Giuliano The stories are fantasies about new kinds of bars that could possibly exist in the future. The Hormesis Bars are ones where all the drinks produce stresses. According … Continue reading →
This gallery contains 23 photos.
By James Watson (with some help from Vince Giuliano) Image source This is the Part 3 of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slowed … Continue reading →
This gallery contains 3 photos.
By James Watson (with editorial help from Vince Giuliano) Image source This is the Part 2 of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slowed … Continue reading →
This gallery contains 22 photos.
By James P Watson and Vince Giuliano Background and introduction There is a wide variety of genetic manipulations, pharmacologic manipulations, and nutrient manipulations that have been shown to alter lifespan in model organisms. These include caloric restriction, “loss of function” … Continue reading →
This gallery contains 21 photos.
Written by James Watson, with major contributions by Vince Giuliano Introduction – Mitochondrial Roles in the Cell This is the second part in a series of blog entries examining the roles of mitochondria in key biological activities. For additional background … Continue reading →