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By Victor Circadian Regulation is a fascinating topic with ties to many issues involved in antiaging research, including the regulation of stem cell populations.(See The circadian molecular clock creates epidermal stem cell heterogeneity, Biological Clock Controls Activation of Skin Stem … Continue reading
By Victor For humans who wish to live long lives, alternative-day fasting may be a better approach than following a restricted calorie diet. The approach avoids premature induction of frailty most likely by periodically inhibiting myogenesis which encourages replenishment of … Continue reading
By Victor In 1934, researchers at Cornell University discovered that laboratory rats fed a severely restricted diet lived up to twice as long as those fed a regular diet. Subsequent research has confirmed the health and longevity benefits of dietary … Continue reading
By Victor Most popular discussions of antioxidants are based on an outdated view of free radicals as evil, toxic compounds, ones which cause chain reactions of destructive damage culminating in degenerative diseases and aging. Research in recent years has revealed … Continue reading
By Victor The August 2011 PLoS Medicine article, Legal Remedies for Medical Ghostwriting discusses legal approaches to combat the prevalent practice of published “academic” studies, which are actually ghostwritten at the behest of pharmaceutical companies. That is right, in many … Continue reading
By Victor “Blue Zones” This is the name given by epidemiologists to places where people tend to have extraordinary lifespans. Sardinia (an Italian island), Ikaria (a Greek island), Okinawa, the Nicoya peninsula of Costa Rica, and Loma Linda California are … Continue reading
By Victor Protein kinases are enzymes which transfer phosphate groups from donors such as ATP to proteins in a process call “phosphorylation”. This process is usually reversible; phosphatases are the enzymes which “dephosphorylate” or remove phosphate groups from proteins. Each … Continue reading
By Victor One of the paradoxes of longevity research has been the observation that persons of exceptional longevity actually have more disease-related genes in their genome than ordinary people. Intuitively, one would expect just the opposite, that the lack of … Continue reading
By Victor Since its discovery in 1979, p53 has never stopped surprising researchers. For a decade, it was thought to be an oncogene (a gene that causes cancer). In 1989, it was found to have the opposite role of suppressing … Continue reading
Normal, healthy, physiological processes are regulated by a complex interplay of numerous, neuroendocrinal signaling pathways. Although there are many intermediary signaling events, the fundamental purpose of most signaling pathways is the transfer of regulatory information to and from the central … Continue reading