http://www.anti-agingfirewalls.com A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. Tue, 07 Feb 2012 16:23:41 +0000 hourly 1 http://wordpress.org/?v=3.2.1 http://www.anti-agingfirewalls.com/2010/04/04/another-piece-of-daf-16-research/#comment-66140 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Tue, 07 Feb 2012 16:23:41 +0000 http://anti-agingfirewalls.com/2010/04/04/another-piece-of-daf-16-research/#comment-66140 [...] metabolism and longevity such as Keap1-Nrf2, AMPK, PI3-kinase, AKT, mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, telomerase, Klotho and NF-kappaB seems to be more important in [...] [...] metabolism and longevity such as Keap1-Nrf2, AMPK, PI3-kinase, AKT, mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, telomerase, Klotho and NF-kappaB seems to be more important in [...]

]]> http://www.anti-agingfirewalls.com/2010/08/27/curcumin-cancer-and-longevity/#comment-66139 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Tue, 07 Feb 2012 16:22:48 +0000 http://anti-agingfirewalls.com/2010/08/27/curcumin-cancer-and-longevity/#comment-66139 [...] have written extensively about the health-producing properties of curcumin (ref)(ref)(ref), The 2010 publication Curcumin, the golden spice from Indian saffron, is a chemosensitizer [...] [...] have written extensively about the health-producing properties of curcumin (ref)(ref)(ref), The 2010 publication Curcumin, the golden spice from Indian saffron, is a chemosensitizer [...]

]]> http://www.anti-agingfirewalls.com/2009/03/15/updates-on-nf-kappab/#comment-66138 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Tue, 07 Feb 2012 16:18:01 +0000 http://anti-agingfirewalls.com/2009/03/15/updates-on-nf-kappab/#comment-66138 [...] mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, telomerase, Klotho and NF-kappaB seems to be more important in assessing the impacts of phytosubstances and their health-producing [...] [...] mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, telomerase, Klotho and NF-kappaB seems to be more important in assessing the impacts of phytosubstances and their health-producing [...]

]]> http://www.anti-agingfirewalls.com/2010/06/28/ampk-and-longevity/#comment-66137 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Tue, 07 Feb 2012 16:17:37 +0000 http://anti-agingfirewalls.com/2010/06/28/ampk-and-longevity/#comment-66137 [...] of pathways involved with metabolism and longevity such as Keap1-Nrf2, AMPK, PI3-kinase, AKT, mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, [...] [...] of pathways involved with metabolism and longevity such as Keap1-Nrf2, AMPK, PI3-kinase, AKT, mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, [...]

]]> http://www.anti-agingfirewalls.com/2012/01/11/dietary-factors-and-dementia-%e2%80%93-part-3-plant-derived-substances-that-can-make-a-difference/#comment-66136 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Tue, 07 Feb 2012 16:16:42 +0000 http://www.anti-agingfirewalls.com/?p=837#comment-66136 [...] have written extensively about the health-producing properties of curcumin (ref)(ref)(ref), The 2010 publication Curcumin, the golden spice from Indian saffron, is a [...] [...] have written extensively about the health-producing properties of curcumin (ref)(ref)(ref), The 2010 publication Curcumin, the golden spice from Indian saffron, is a [...]

]]> http://www.anti-agingfirewalls.com/2009/10/21/nrf2-and-cancer-chemoprevention-by-phytochemicals/#comment-66135 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Tue, 07 Feb 2012 16:16:15 +0000 http://anti-agingfirewalls.com/2009/10/21/nrf2-and-cancer-chemoprevention-by-phytochemicals/#comment-66135 [...] rather extensively about phytochemicals and how they activate the Nrf2 pathway.  In my blog entry Nrf2 and cancer chemoprevention by phytochemicals I indicated “A cluster of research reports has appeared during the last few years looking at [...] [...] rather extensively about phytochemicals and how they activate the Nrf2 pathway.  In my blog entry Nrf2 and cancer chemoprevention by phytochemicals I indicated “A cluster of research reports has appeared during the last few years looking at [...]

]]> http://www.anti-agingfirewalls.com/2012/02/06/the-pivotal-role-of-nrf2-part-2-%e2%80%93-foods-phyto-substances-and-other-substances-that-turn-on-nrf2/#comment-66041 The pivotal role of Nrf2. Part 1 – a new view on the control of oxidative damage and generation of hormetic effects | AGING SCIENCES – Anti-Aging Firewalls Mon, 06 Feb 2012 19:44:50 +0000 http://www.anti-agingfirewalls.com/?p=884#comment-66041 [...] AGING SCIENCES – Anti-Aging Firewalls A weblog on the sciences and practices of living healthily very long – perhaps hundreds of years. Skip to content Home ← Circadian Regulation, NMN, Preventing Diabetes, and Longevity The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 ... [...] [...] AGING SCIENCES – Anti-Aging Firewalls A weblog on the sciences and practices of living healthily very long – perhaps hundreds of years. Skip to content Home ← Circadian Regulation, NMN, Preventing Diabetes, and Longevity The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 … [...]

]]> http://www.anti-agingfirewalls.com/2011/05/09/longevity-and-the-gh%e2%80%93igf-axis/#comment-66040 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Mon, 06 Feb 2012 19:40:30 +0000 http://anti-agingfirewalls.com/2011/05/09/longevity-and-the-gh%e2%80%93igf-axis/#comment-66040 [...] metabolism and longevity such as AMPK, PI3-kinase, AKT, mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, telomerase, Klotho and NF-kappaB seems to be more important in assessing the [...] [...] metabolism and longevity such as AMPK, PI3-kinase, AKT, mTOR, MAPK, PPAR-gamma, FoxO/DAF-16, the GH-IGF axis, P16(Ink4a), SIRT1, telomerase, Klotho and NF-kappaB seems to be more important in assessing the [...]

]]> http://www.anti-agingfirewalls.com/2011/12/26/focus-on-phytosubstances-%e2%80%93-danshen-root-amazing-properties-of-salvia-miltiorrhiza-bunge/#comment-66039 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Mon, 06 Feb 2012 19:40:14 +0000 http://www.anti-agingfirewalls.com/?p=811#comment-66039 [...] the December 2011 blog entry Focus on phytosubstances – Danshen root – amazing properties of salvia miltiorrhiza Bunge, I reported on the December 2011 publication Extract of Salvia miltiorrhiza (Danshen) induces [...] [...] the December 2011 blog entry Focus on phytosubstances – Danshen root – amazing properties of salvia miltiorrhiza Bunge, I reported on the December 2011 publication Extract of Salvia miltiorrhiza (Danshen) induces [...]

]]> http://www.anti-agingfirewalls.com/2011/05/18/focus-on-ginger/#comment-66038 The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2 | AGING SCIENCES – Anti-Aging Firewalls Mon, 06 Feb 2012 19:39:34 +0000 http://anti-agingfirewalls.com/2011/05/18/focus-on-ginger/#comment-66038 [...] I have written before rather extensively about phytochemicals and how they activate the Nrf2 pathway.  In my blog entry Nrf2 and cancer chemoprevention by phytochemicals I indicated “A cluster of research reports has appeared during the last few years looking at mechanisms through which substances rich in phytochemicals (e.g. coffee, chocolate, turmeric, olive oil, broccoli, red hot peppers, green tea, garlic, blueberries, rosemary, oregano, sage) are cancer-preventative. While these foods have been studied for many years a new focal point has been moving to center stage – study of what these substances are doing in terms of gene expression as a key to understanding their therapeutic value. — Recent studies have provided strong evidence that many daily-consumed dietary compounds possess cancer-protective properties that might interrupt the carcinogenesis process. These properties include the induction of cellular defense detoxifying and antioxidant enzymes, which can protect against cellular damage caused by environmental carcinogens or endogenously generated reactive oxygen species. These compounds can also affect cell-death signaling pathways, which could prevent the proliferation of tumor cells.” — One master activator of antioxidant and anticancer genes appears to be Nuclear factor-erythroid-2-related factor 2 (Nrf2). The sequence of events involved in phytochemical chemoprevention mediated by Nrf2 is complex and is summarized in the 2008 publication Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. “A wide array of dietary phytochemicals have been reported to induce the expression of enzymes involved in both cellular antioxidant defenses and elimination/inactivation of electrophilic carcinogens. Induction of such cytoprotective enzymes by edible phytochemicals largely accounts for their cancer chemopreventive and chemoprotective activities.”  I also repeated much of the same information related to Nrf2 in the May 2011 blog entry Focus on ginger [...] [...] I have written before rather extensively about phytochemicals and how they activate the Nrf2 pathway.  In my blog entry Nrf2 and cancer chemoprevention by phytochemicals I indicated “A cluster of research reports has appeared during the last few years looking at mechanisms through which substances rich in phytochemicals (e.g. coffee, chocolate, turmeric, olive oil, broccoli, red hot peppers, green tea, garlic, blueberries, rosemary, oregano, sage) are cancer-preventative. While these foods have been studied for many years a new focal point has been moving to center stage – study of what these substances are doing in terms of gene expression as a key to understanding their therapeutic value. — Recent studies have provided strong evidence that many daily-consumed dietary compounds possess cancer-protective properties that might interrupt the carcinogenesis process. These properties include the induction of cellular defense detoxifying and antioxidant enzymes, which can protect against cellular damage caused by environmental carcinogens or endogenously generated reactive oxygen species. These compounds can also affect cell-death signaling pathways, which could prevent the proliferation of tumor cells.” — One master activator of antioxidant and anticancer genes appears to be Nuclear factor-erythroid-2-related factor 2 (Nrf2). The sequence of events involved in phytochemical chemoprevention mediated by Nrf2 is complex and is summarized in the 2008 publication Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. “A wide array of dietary phytochemicals have been reported to induce the expression of enzymes involved in both cellular antioxidant defenses and elimination/inactivation of electrophilic carcinogens. Induction of such cytoprotective enzymes by edible phytochemicals largely accounts for their cancer chemopreventive and chemoprotective activities.”  I also repeated much of the same information related to Nrf2 in the May 2011 blog entry Focus on ginger [...]

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