Search Results for: DNA methylation

Healthy, active and productive till 100. Laying out the Adult Aging Process, a Breakthrough and my Personal Story

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By Vince Giuliano The causal chain of events leading to advanced human aging has only been clarified very recently.  A key step in this causal chain is systemic inflammation leading to accelerated epigenetic aging.  In reports of other researcher and … Continue reading

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Two faces of Life Extension

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By Vince Giuliano There are two distinct faces of life extension which are often confused, even by the best researchers working in the longevity field.  This sometimes leads to paradoxical observations.  I seek to clarify what these faces are in … Continue reading

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DEEPER INTO THE EPIGENETICS OF YOUNGING 1.1 — INTERACTIONS OF H3K9, H3K4, H3K27, H3K79 AND BIVALENT HISTONE POST-TRANSLATIONAL MODIFICATION (PMT) DOMAINS

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By Vince Giuliano.  With contributions, suggestions and editing by members of the YOUNGING team: Steve Buss, Walter Crompton, Chris Wikman and Debbie Coehlo 5-1-2022 GENERAL CONTEXT From the onset some 12 years ago, this anti-agingfirewalls blog has followed an implicit Mission … Continue reading

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Biometrics and Aging

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By A. Christopher Wikman, March 2022 INTRODUCTION Over the years, this weblog has brought to light, integrated and presented the science of aging and the healthy practices and interventions (see the post “PRACTICAL INTERVENTIONS FOR YOUNGING1.0 – Introduction to the … Continue reading

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ONLINE PRESENTATION – Extensions to Triggering Ancient Mechanisms For Rejuvenation — Online user comments, questions asked, and selected post-Meetup responses

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By Vince Giuliano and Steve Buss As announced previously, on November 20 2021 Steve Buss and I were featured in an online Meetup of the London Futurist group.  We focused on delivering a coherent presentation of our research reported in … Continue reading

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YGD YOUNGING1.0 PART 4: UNDERLYING MECHANISMS OF YOUNGING 1.0. HSC STEM CELL DIFFERENTIATION

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By Vince Giuliano Art KOUKOU by Vince Giuliano I.   INTRODUCTION AND BACKGROUND YOUNGING processes in the human body are like AGING processes in reverse. I have suggested that there are natural YOUNGING processes normally going on in mature humans, along … Continue reading

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YGC MORE ON YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY

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I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via  JMJD2/JMJD3.  I go deeper into the biology and processes of histone methylation – and relate these to longevity and YOUNGING01. Continue reading

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YGB YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY

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By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING  Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments). After reading the present … Continue reading

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AGING, CELL AND TISSUE REPAIR, RENEWAL AND REGENERATION, INFLAMMATION AND THE SASP

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By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have … Continue reading

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Part 2 of interventions that reduce all cause mortality (ACM) – Metformin

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by James P Watson and Vince Giuliano There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably … Continue reading

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