Category Archives: Uncategorized

This blog entry provides an update on 2010 research relating to how certain everyday factors such as lifestyle, exercise and diet affect telomere lengths.  This is the second in a 3-part mini-series of blog posts concerned with the implications of … Continue reading →

Telomere lengths and the complex processes of telomere homeostasis are being researched intensively from a number of viewpoints.   However, it has been some time since I have discussed issues related to telomere lengths in this blog.  In this Part 1 … Continue reading →

One theory of aging is that the genome and other DNA of an organism accumulate increasing numbers of errors with age and that these errors are responsible for the macroscopic phenomenon we call “aging.” See the second theory of aging … Continue reading →

A small biotech company, ImmunoGen, has been developing targeted therapies for cancers, therapies based on attaching anticancer drug payloads to antibodies that home in on cancer cells.  This is another “guided missile” strategy that promises to increase the efficacy and … Continue reading →

A newly-reported breakthrough in technology for generating high-fidelity induced pluripotent stem cells (iPSCs) suggests that these cells will soon be available and safe for use for in people.  The implications for regenerative medicine and extending human longevity may be profound.  … Continue reading →

Marios Kyriazis has invited me to engage with him in a dialog about the possibility of indefinite life extension and our first e-mail exchange is included here.  Dr. Kyriazis is a well-known physician and researcher in the field of anti-aging … Continue reading →

The stage for this blog entry was set by the recent one If we can multiply lifespans of nematodes by seven, why have we not been able to get anywhere with significant human lifespan extension?  The way things are going … Continue reading →

Back in a July 2009 blog post Life extension by a factor of 10, I described how radical life extension has been achieved in baker’s yeast.  The most-recent blog entry posted two days ago New extraordinary longevity lessons from the … Continue reading →

Genetic lifespan regulation has been studied extensively in the nematode roundworm Caenorhabditis elegans (C-elegans) since the 1980s.  Hundreds of research papers have been written on this topic.  And I have generated a number of blog entries on longevity pathways known … Continue reading →

The October 2009 blog entry Klotho anti-aging gene in the news describes how the Klotho protein exhibits anti-aging effects in mice when over-expressed and accelerates aging when under-expressed, Klotho’s role with respect to the vitamin D receptor (VDR),  and how … Continue reading →