Category Archives: Uncategorized

The P53 protein provides a first line of defense against cancers, causing cancer cells to commit apoptosis.  “p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 … Continue reading →

In the post Diabetes Part I: Biology and molecular dynamics of diabetes, I described a pathological biomolecular process through which diabetes arises from obesity or metabolic syndrome.  I also provided reference links to publications amplifying on the details of the … Continue reading →

This is the first of two related blog posts on diabetes.  Here I review the nature of diabetes, and a commonly occurring biomolecular processes underlying the development of Type 2 diabetes.  I quote from several recent research papers relating diabetes … Continue reading →

At the still-ongoing (as of July 12, 2010) meeting of the American Alzheimer’s Association in Honolulu, four different papers were presented that  validate components of the anti-aging firewalls regimen suggested in my treatise Anti-Aging Firewalls – The Science and Technology … Continue reading →

I have written about developments relating to cell reprogramming and induced pluripotent stem cells (iPSCs) in several previous blog posts, the most recent including A near-term application for iPSCs – making cell lines for drug testing, Induced pluripotent stem cells … Continue reading →

Longevity science had been a hobby for me for a long time and about 3 years ago I decided to pursue it as a new full-time career.  I put the first version of my treatise Anti-Aging Firewalls – The Science … Continue reading →

Hormesis is a process through which moderate stress induces a body response that is protective against insults, confers health and possibly even longevity benefits.  The process of hormesis is thought to be mediated primarily via heat shock proteins (HSPs).  An … Continue reading →

The AMPK signaling pathway is one that is increasingly being viewed as playing a central role in metabolism and growth(ref). And that pathway appears to have a lot to do with longevity.  In fact, it is possible that some degree … Continue reading →

I have frequently asserted that telomere lengths do not decline in a uniform manner through life but depend on the interaction of multiple endogenous and extrinsic factors.  Two important factors are stress and exercise.  A new study in Plos One … Continue reading →

Ever hear of humanin?  At the Paul K Glenn Symposium on Aging yesterday at Harvard, Dr. Pinchas Cohen gave a talk on The New World of Mitochondrial Proteins featuring humanin and other closely related proteins.  The subject is important because … Continue reading →