Category Archives: Uncategorized

Up until a couple of months ago, the answer seemed very clear to me.  Resveratrol offers a number of powerful health-promoting effects.  Also, it turns on the SIRT1 gene activating the same evolutionary-conserved pathway that is known to confer longevity … Continue reading →

Astragalus-based dietary supplements that are known to activate the expression of telomerase have been on the market for several years now.  However, there appears to be a significant difference between what these supplements are widely publicized to do and what … Continue reading →

I have reported on Induced pluripotent stem cells (iPSCs) in my treatise and in numerous past blog entries(ref)(ref)(ref).  I have viewed these cells as probably providing  the golden keys to closing the loop on the stem cell supply chain allowing … Continue reading →

At least three approaches to human longevity that have been discussed multiple times in this blog appear to be in trouble or the subject of controversy between groups of scientists: 1.  generation and use of effective and reliable induced pluripotent stem … Continue reading →

How do we know if something we read about longevity is so?  This post is stimulated by the previous blog entry Another piece of DAF-16 research.  I list a few comments having to do with the creditability of longevity research … Continue reading →

Some of the popular media touted new April 2010 research as heralding the discovery of a new gene(e.g., AOL news(ref)), but what the new piece of research does is only add another perspective to a long-developing story on how the … Continue reading →

This blog entry is intended to clarify what aging, life extension and anti-aging are about.  It suggests a new way of looking at the theories of aging in my treatise ANTI-AGING FIREWALLS THE SCIENCE AND TECHNOLOGY OF LONGEVITY. It is … Continue reading →

It was disturbing to some readers when I characterized niacinamide as a pro-aging substance in the March 24 blog post  SIRT1, mTOR, NF-kappaB and resveratrol, as it was disturbing to me when I first came to that realization years ago.  … Continue reading →

In the recent blog entry SIRT1, mTOR, NF-kappaB and resveratrol, I pointed out how “three different theories of longevity seem to be collapsing into one: 1. suppression of mTOR signaling, 2. activation of SIRT1, and 3. inhibition of expression of … Continue reading →

A few days ago I visited Leonard Guarante, Director of the Glenn Laboratory for the Science of Aging at MIT and pioneer in the investigation of sirtuins and their longevity properties.  The lead line of the Laboratory’s web site is … Continue reading →