Author Archives: Vince Giuliano

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 96. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. As of November 2025, I believe the longevity interventions I have already published in this blog and are being followed by me will easily get me to age 100 and somewhat beyond, still healthy, highly functional and working Further, I have been researching and will be pubishing about additional interventions which I expect will buy me several additional years of active healthy living. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.

Genomic stability, DNA repair and the sirtuin SIRT6

One theory of aging is that the genome and other DNA of an organism accumulate increasing numbers of errors with age and that these errors are responsible for the macroscopic phenomenon we call “aging.” See the second theory of aging … Continue reading

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Another guided-missile cancer therapy – that works

A small biotech company, ImmunoGen, has been developing targeted therapies for cancers, therapies based on attaching anticancer drug payloads to antibodies that home in on cancer cells.  This is another “guided missile” strategy that promises to increase the efficacy and … Continue reading

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A breakthrough in producing high-fidelity induced pluripotent stem cells

A newly-reported breakthrough in technology for generating high-fidelity induced pluripotent stem cells (iPSCs) suggests that these cells will soon be available and safe for use for in people.  The implications for regenerative medicine and extending human longevity may be profound.  … Continue reading

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Indefinite life extension – Dialog with Marios Kyriazis

Marios Kyriazis has invited me to engage with him in a dialog about the possibility of indefinite life extension and our first e-mail exchange is included here.  Dr. Kyriazis is a well-known physician and researcher in the field of anti-aging … Continue reading

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Gearing up for the war on aging

The stage for this blog entry was set by the recent one If we can multiply lifespans of nematodes by seven, why have we not been able to get anywhere with significant human lifespan extension?  The way things are going … Continue reading

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If we can multiply lifespans of nematodes by seven, why have we not been able to get anywhere with significant human lifespan extension?

Back in a July 2009 blog post Life extension by a factor of 10, I described how radical life extension has been achieved in baker’s yeast.  The most-recent blog entry posted two days ago New extraordinary longevity lessons from the … Continue reading

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New extraordinary longevity lessons from the nematode

Genetic lifespan regulation has been studied extensively in the nematode roundworm Caenorhabditis elegans (C-elegans) since the 1980s.  Hundreds of research papers have been written on this topic.  And I have generated a number of blog entries on longevity pathways known … Continue reading

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Klotho, phosphates, cola drinks and longevity

The October 2009 blog entry Klotho anti-aging gene in the news describes how the Klotho protein exhibits anti-aging effects in mice when over-expressed and accelerates aging when under-expressed, Klotho’s role with respect to the vitamin D receptor (VDR),  and how … Continue reading

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Smurf2 in senescence, aging and diseases

Smurf2 is a fascinating gene and enzyme that plays a number of key roles throughout life in people, ranging from roles in embryonic development and stem cell differentiation to ones relating to cell senescence and accelerated (or delayed) aging.  It … Continue reading

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HSP70 to the rescue – But, no, no! That’s not what we want for cancer cells

The July 2010 blog entry HSP70 to the rescue describes how heat shock protein 70 (HSP70) works to promote survival of cells under stress and provides examples of the positive hormetic effects of this chaperone protein.  For example HSP70 is … Continue reading

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