Author Archives: Vince Giuliano

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 96. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. As of November 2025, I believe the longevity interventions I have already published in this blog and are being followed by me will easily get me to age 100 and somewhat beyond, still healthy, highly functional and working Further, I have been researching and will be pubishing about additional interventions which I expect will buy me several additional years of active healthy living. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.

Valproic acid – The phoenix drug arises again

The chemical valproic acid has been around for a very long time.  It was first synthesized in 1882 and for a great many years it seemed to be not very useful. However, over its 128 year history valproic acid has … Continue reading

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Antagonistic pleiotropy revisited – for the last time

Most times when I meet old friends who I have not seen for a long time, the old magic comes back.  There is new vitality in our new context of relationship.  With certain other people met again after many years, … Continue reading

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Curcumin, cancer and longevity

This blog entry is a companion and sequel to the previous one Neurogenesis, curcumin and longevity.  I focus here on the extensive research related to the anti-cancer properties of curcumin and go further into an issue raised in the last … Continue reading

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Neurogenesis, curcumin and longevity

I have discussed both neurogenesis and curcumin in my treatise and in numerous blog entries but have never examined their relationship.  This blog entry is about the actions of curcumin in promoting neurogenesis in the hippocampus and highly-likely mental-health implications … Continue reading

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PGC-1-alpha and exercise

You can probably expect to hear a lot about PGC-1-alpha as time goes on because this remarkable substance is turning out to have a lot to do with health and longevity.  It appears to be the mediator of the health … Continue reading

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Blog entries in the works

I have covered much of the “low hanging fruit” of the longevity sciences in the 304 existing blog entries written over the last two years.  Yet, developing a comprehensive understanding of the key aspects of aging requires harvesting fruit from … Continue reading

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Skin Cancer immunotherapies

Immunotherapies are ones that mobilize the body’s own immune system defense against disease processes.  This blog entry is about immunotherapies for skin cancers, focusing on an effective older one known as imiquimod or by its trade name aldara, and a … Continue reading

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Contrarian research findings: newly-identified aging villain substances; calorie restriction longevity is not due to calorie restriction

Recent publications have surfaced substances that may contribute to aging including favorites used to extend longevity.  Also, it has cast light on longevity due to calorie restriction suggesting that what counts is not the calories as much as the food … Continue reading

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Turning P53 on in cancer cells

The P53 protein provides a first line of defense against cancers, causing cancer cells to commit apoptosis.  “p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 … Continue reading

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Diabetes Part 2: Lifestyle, dietary and supplement interventions

In the post Diabetes Part I: Biology and molecular dynamics of diabetes, I described a pathological biomolecular process through which diabetes arises from obesity or metabolic syndrome.  I also provided reference links to publications amplifying on the details of the … Continue reading

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