Category Archives: Uncategorized

Contrarian current research outcomes

This blog entry is about three recent research results where the outcomes were the opposite of what might have been expected.  1.     Chocolate consumption and depression are correlated  The April 2919 publication Chocolate and Depressive Symptoms in a Cross-sectional Analysis indicates … Continue reading

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Alzheimer’s Disease research update

I have posted several blog entries related to Alzheimer’s Disease (AD), including  New views of Alzheimer’s disease and new approaches to treating it,  The social cost of Alzheimer’s disease and late-life dementia, Diet and cognition, Warding off Alzheimer’s Disease and … Continue reading

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Extra-virgin olive oil

As a kid in a traditional Italian family, I was raised on olive oil.  And I now consume generous quantities of extra-virgin olive oil (EVOO) just about every day.  For one thing, I love its taste.  I am so hooked … Continue reading

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The PROOF Centre of Excellence

In the recent blog post Harnessing the engines of finance and commerce for life-extension, I characterized a new approach to health, medicine and  longevity called Personalized Predictive Preventative Participatory Medicine (PPPPM). I also promised to describe specific examples in subsequent blog … Continue reading

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Towards a systems view of aging

On several occasions both in this blog and in my treatise I have pointed out the need for integrating the various disparate theories of aging into an overall systems framework.  Following is the abstract for a presentation I will be … Continue reading

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Harnessing the engines of finance and commerce for life-extension

Suppose I reported that billions of dollars will be spent on life-extension research next year and that soon that number will reach tens of billions?  The first reaction of aging-science researchers would be “no way.”  They would point to the … Continue reading

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Out at the Bio-IT conference

I am out attending the Bio-IT World Conference & Expo in Boston a good part of this week, paying particular attention to the track on Systems and Predictive Technology.  The conference is focused on a fundamental shift happening in biological and medical research, … Continue reading

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Progress in stem cell oncolytic virotherapy

Don’t let the fancy name scare you off.  The underlying concepts are fairly simple.  The basic idea is to go after cancer cells with viruses that kill them.  To help the viruses escape the immune system, they are packaged in … Continue reading

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DNA Methyltransferases, stem cell proliferation and differentiation

Perhaps the two most comprehensive theories explaining aging in my treatise are Programmed Epigenomic Changes and Stem Cell Supply Chain Breakdown.  Recent research related to the epigenetics of stem cells deals with the profound underlying relationships between those two theories.  … Continue reading

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More on DNA repair strategies

DNA repair is a major defense against the second cause of aging described in my treatise Cell DNA Damage.  Such repair is absolutely necessary. Damage can be caused by oxidative processes, radiation exposure, and exposure to environmental toxins, cigarette smoke … Continue reading

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