Category Archives: Uncategorized

The free radical theory of aging, also known as the Oxidative Damagetheory of aging is over 50 years old and is perhaps the most-studied and most venerable of all the theories of aging.   But at least one line of … Continue reading →

Have you heard about Ghrelin?  No, I am not talking about a new grill cleaner or a men’s girl-attracting perfume or a new shortstop for the Yankees.  Ghrelin is a hormone deeply involved in a very important current health condition, … Continue reading →

I wrote about blueberries back in September 2009 in the blog entry Blueberries and health – the research case, citing 11 research citations there on their positive health effects.  I have long been in the habit of eating a cupful … Continue reading →

I have written about calorie restriction (CR) a number of times in this blog. CR is the most-proven approach to life extension, involving an ancient biological pathway that works across a variety of species. This blog entry focuses on CR … Continue reading →

Virtually everybody has taken acetaminophen (also known as paracetamol) from time to time; probably a lot of it over the years.  It is of course the key ingredient in the over-the-counter pain-killer Tylenol®,  is widely sold as an inexpensive over-the-counter … Continue reading →

I have written a number of times in this blog about iPSCs (induced pluripotent stem cells) including the exciting possibility of closing the loop in the stem cell supply chain and thereby enabling very long lives.  See the posts IPSCs, … Continue reading →

In my presentation Towards a Systems Theory of Aging I argue that the two theories Programmed epigenomic changes and Decline in functioning of the stem cell supply chain are complimentary and equivalent and have the potential for providing a framework … Continue reading →

The p21 gene has long been known for its role in cell cycle arrest and apoptosis.  In case of DNA damage it signals to the p53 gene to initiate apoptosis of the cell, averting the possibility of tumorgenesis.  Very-recent research … Continue reading →

I have finished drafting the Power Point presentation for the Society’s 39th annual meeting in Portland Oregon early next month.   I am still polishing up the presentation, fixing mysteriously broken links, adding citations, etc., but I have put it online … Continue reading →

Melanoma is the most serious form of skin cancer. It is a cancer “–  of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma).  — Melanocytes are normally present in skin, … Continue reading →