Warding off Alzheimer’s Disease and things in my diet

I thought I would poke into what the research literature says about things in my diet and associated risk of Alzheimer’s disease or late-onset dementia.  I came up with the following”

My morning cups of coffee (3-4 cups, half-caffeinated, half decaff): 

“Coffee drinkers at midlife had lower risk of dementia and AD later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, apolipoprotein E ε4 allele and depressive symptoms. The lowest risk (65% decreased) was found in people who drank 3-5 cups per day(ref).” “Middle-aged people who drank between three and five cups of coffee a day lowered their risk of developing dementia and Alzheimer’s disease by between 60 and 65 percent later in life,” said lead researcher on the project, Miia Kivipelto, a professor at the University of Kuopio in Finland and at the Karolinska Institute in Stockholm(ref). A just-out study goes further and suggests that lots of coffee can possibly reverse symptoms of Alzheimer’s Disease: “New research from the US and Japan showed that giving the caffeine equivalent of five cups of coffee a day to aged mice with symptoms of Alzheimer’s reversed two signs of the disease: it reversed memory impairment and reduced the hallmark protein in the animals’ blood and brains(ref).”  See my earlier post Phytochemicals – focus on caffeic acid.

My usual breakfast: a sugar-free bran cereal with blueberries, walnuts and a sliced half-banana.

From Science News: Diet Of Walnuts, Blueberries Improve Cognition; May Help Maintain Brain Function(ref): “Diets containing two percent, six percent, or nine percent walnuts, when given to old rats, were found to reverse several parameters of brain aging, as well as age-related motor and cognitive deficits, says James Joseph, PhD, of the U.S. Department of Agriculture Human Nutrition Research Center at Tufts University in Boston.” – “Diets containing two percent, six percent, or nine percent walnuts, when given to old rats, were found to reverse several parameters of brain aging, as well as age-related motor and cognitive deficits, says James Joseph, PhD, of the U.S. Department of Agriculture Human Nutrition Research Center at Tufts University in Boston.” “This information, coupled with our previous studies, shows that the addition of walnuts, berries, and grape juice to the diet may increase ‘health span’ in aging and provide a ‘longevity dividend’ or economic benefit for slowing the aging process by reducing the incidence and delaying the onset of debilitating degenerative disease.” Six percent walnuts is equivalent to about an ounce a day which is what I have been eating. A British study reported in April 2009 confirms the value of walnuts for enhancing the ability of the connections between neurons to change in strength and function in aging rodents, and also to limiting oxidative damage to neural tissue. In aged rodents(ref).  Oh yes, and then there is the half- banana.  Another research report indicates “”Our results suggest that fresh apples, banana and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer’s disease,” Lee concluded(ref).”

My daily fruit snacks (apple, cherries, plum, grapes, nectarine)

Previous reference applies.

My daily chocolate snack

“Oxidative stress induced by reactive oxygen species has been strongly associated with the pathogenesis of neurodegenerative disorders, including Alzheimer’s disease. In this study, we investigated the possible protective effects of a cocoa procyanidin fraction (CPF) and procyanidin B2 (epicatechin-(4beta-8)-epicatechin) – a major polyphenol in cocoa – against apoptosis of PC12 rat pheochromocytoma (PC12) cells induced by hydrogen peroxide.  – These results suggest that the protective effects of CPF and procyanidin B2 against H(2)O(2)-induced apoptosis involve inhibiting the downregulation of Bcl-X(L) and Bcl-2 expression through blocking the activation of JNK and p38 MAPK(ref).”  So, chocolate might help too and reduce cardiovascular risk as well(ref).

Glass of red wine (1-2 days a week)

“We recently found that moderate consumption of two un-related red wines generate from different grape species, a Cabernet Sauvignon and a muscadine wine that are characterized by distinct component composition of polyphenolic compounds, significantly attenuated the development of Alzheimer’s disease (AD)-type brain pathology and memory deterioration in a transgenic AD mouse model. Interestingly, our evidence suggests that the two red wines attenuated AD phenotypes through independent mechanisms. In particular, we previously found that treatment with Cabernet Sauvignon reduced the generation of AD-type amyloid-β (Aβ) peptides. In contrast, evidence from our present study suggests that muscadine treatment attenuates Aβ neuropathology and Aβ-related cognitive deterioration in Tg2576 mice by interfering with the oligomerization of Aβ molecules to soluble high-molecular-weight Aβ oligomer species that are responsible for initiating a cascade of cellular events resulting in cognitive decline. Collectively, our observations suggest that distinct polyphenolic compounds from red wines may be bioavailable at the organism level and beneficially modulate AD phenotypes through multiple Aβ-related mechanisms(ref).”  See my previous post in this blog Half glass of wine a day – good for longevity or bad because of increased cancer risk?   

Salami, prosciutto or corned beef sandwich, hot dog, bacon, hamburger, Polish or Italian sausage- once a week?

It would not be honest to represent everything I eat as good for me.  Occasionally, perhaps once or twice a week, I will partake of processed meat.  Usually this is in a restaurant, ball park or other place where I cannot check on the preservatives used. “Preservatives added to cured meats, bacon and ground beef have been linked to dementia diseases such as Alzheimer’s and Parkinson’s.”  – “Scientists say sodium nitrite, which is added to meat and fish to destroy toxins, reacts with proteins in the meat, damaging human DNA cells similar to aging(ref).” “U.S. researchers say they have found a substantial link between increased levels of nitrates in the environment and in food and increased deaths from Alzheimer’s, Parkinson’s and Type 2 diabetes. –The study, published this month in the Journal of Alzheimer’s Disease, found “strong parallels” between age-adjusted increases in the death rate from those diseases and the progressive increases in human exposure to nitrates and nitrosamines through processed and preserved foods, as well as through fertilizers(ref).

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.
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10 Responses to Warding off Alzheimer’s Disease and things in my diet

  1. DeadMeat says:

    Hi Vince

    Perhaps you find this article about the water extract of cinnamon against tau tangles interesting.
    http://www.ncbi.nlm.nih.gov/pubmed/19433898
    “An aqueous extract of Ceylon cinnamon (C. zeylanicum) is found to inhibit tau aggregation and filament formation, hallmarks of Alzheimer’s disease (AD). The extract can also promote complete disassembly of recombinant tau filaments and cause substantial alteration of the morphology of paired-helical filaments isolated from AD brain. Cinnamon extract was not deleterious to the normal cellular function of tau, namely the assembly of free tubulin into microtubules.”

    And some anecdotal evidence.
    http://www.alzinfo.org/forum/viewtopic.php?t=2
    http://alzheimers.infopop.cc/eve/forums/a/tpc/f/675102261/m/6051008062

    Also see this very interesting info about lithium aspartate(not to be confused with lithium carbonate).
    http://www.nia.nih.gov/Alzheimers/ResearchInformation/NewsReleases/Archives/PR2003/PR20030521lithium.htm
    “An enzyme crucial to formation of Alzheimer’s plaques and tangles may hold promise as a target for future medications, suggest studies in mice and cells. By blocking the enzyme, lithium stems the accumulation of beta amyloid, which forms Alzheimer’s plaques, scientists funded by the National Institutes of Health (NIH) report in the May 22, 2003 “Nature.” Inhibiting the enzyme, glycogen synthase kinase – 3 alpha (GSK-3 alpha), also blocks formation of neurofibrilary tangles by the “tau” protein.”

    And a very nice article about it and its other neuroprotective effects.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17572175

    And this thread.
    http://www.alzinfo.org/forum/viewtopic.php?t=27&sid=737f20392c196c36cbf7e8e328c0decf

  2. admin says:

    Deadmeat:
    Thank you very much for posting these referenes. I have seen the ones about lithium and cimnamon but the others are new to me. Lithium is an amazing substance and I have thought about writing about it. While not about foods I eat your items do lend a lot of depth to the question of what to do to ward off Alzheimer’s disease dementia. A great contribution. Vince

  3. Res says:

    Did you forget curcumin aka turmeric for alzheimars?

  4. admin says:

    Res
    Of course you are right about curcumin, and a number of other substances in the firewall against neurological degeneration are also important. I did not mention them in this blog post because the post was only about daily foods, not supplements. vince

  5. MachineGhost says:

    Hormel now sells nitrate-free lunchmeat:

    http://www.hormelnatural.com/

    The high pressure technology that was invented and used is an interesting read elsewhere.

    Also, Trader Joe’s sells “uncured” bacon, hot dogs and lunchmeat. However, most brands moronically add concentrated celery juice which contains naturally occuring nitrates.

  6. admin says:

    MachineGhost

    Yes vegetables and vegetable drinks like celery juice can contain a lot of nitrates that convert to nitrites in the body. It is very difficult to get away from them since vegetables seem to be among the most healthy foods.
    Vince

  7. Brian Marcks says:

    I add spermitine rich foods to my diet as studies have shown it extends life span in yeast, fruit flies, mice, etc. about as much as Resveratrol.

  8. admin says:

    Brian Marcks:

    Thanks. I don’t know much about spermatine but am adding it to the growing list of things I want to look into,

    Vince

  9. Pingback: Alzheimer’s Disease Update – March 2011 | AGING SCIENCES – Anti-Aging Firewalls

  10. Pingback: Health and longevity benefits of plant polyphenols – focus grape seed extract | AGING SCIENCES – Anti-Aging Firewalls

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