Author Archives: Vince Giuliano

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 96. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. As of November 2025, I believe the longevity interventions I have already published in this blog and are being followed by me will easily get me to age 100 and somewhat beyond, still healthy, highly functional and working Further, I have been researching and will be pubishing about additional interventions which I expect will buy me several additional years of active healthy living. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.

Induced pluripotent stem cells – second-rate stem cells so far

I have reported on Induced pluripotent stem cells (iPSCs) in my treatise and in numerous past blog entries(ref)(ref)(ref).  I have viewed these cells as probably providing  the golden keys to closing the loop on the stem cell supply chain allowing … Continue reading

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Setting the record straight on three favorite approaches to longevity

At least three approaches to human longevity that have been discussed multiple times in this blog appear to be in trouble or the subject of controversy between groups of scientists: 1.  generation and use of effective and reliable induced pluripotent stem … Continue reading

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Believing news reports and scientific publications

How do we know if something we read about longevity is so?  This post is stimulated by the previous blog entry Another piece of DAF-16 research.  I list a few comments having to do with the creditability of longevity research … Continue reading

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Another piece of DAF-16 research

Some of the popular media touted new April 2010 research as heralding the discovery of a new gene(e.g., AOL news(ref)), but what the new piece of research does is only add another perspective to a long-developing story on how the … Continue reading

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What are aging, life-extension and anti-aging?

This blog entry is intended to clarify what aging, life extension and anti-aging are about.  It suggests a new way of looking at the theories of aging in my treatise ANTI-AGING FIREWALLS THE SCIENCE AND TECHNOLOGY OF LONGEVITY. It is … Continue reading

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Niacin or niacinamide supplementation – good or bad idea?

It was disturbing to some readers when I characterized niacinamide as a pro-aging substance in the March 24 blog post  SIRT1, mTOR, NF-kappaB and resveratrol, as it was disturbing to me when I first came to that realization years ago.  … Continue reading

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SIRT1, the hypoxic response, autophagy and hormesis

In the recent blog entry SIRT1, mTOR, NF-kappaB and resveratrol, I pointed out how “three different theories of longevity seem to be collapsing into one: 1. suppression of mTOR signaling, 2. activation of SIRT1, and 3. inhibition of expression of … Continue reading

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Visit with Leonard Guarante

A few days ago I visited Leonard Guarante, Director of the Glenn Laboratory for the Science of Aging at MIT and pioneer in the investigation of sirtuins and their longevity properties.  The lead line of the Laboratory’s web site is … Continue reading

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SIRT1, mTOR, NF-kappaB and resveratrol

Among the few interventions that demonstrably extend lifespans across multiple species besides calorie restriction are 1. inhibition of the mTOR pathway, 2. the activation of sirtuins such as via calorie restriction or substances such as resveratrol, and 3. Inhibition of … Continue reading

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Cell import and export traffic control signaling

Mechanisms for getting stuff into and out of cells are of great importance.  A new item of research came to my attention related to substance-trafficking that goes on within cells and across cell membrane barriers.  It has relevancy in terms … Continue reading

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