Blog Archives

Inflammation Part 5: Inflammasomes – science of and disease implications

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By James P. Watson and Vince Giuliano Inflammasomes are multimeric self-assembling protein complexes within the cytosol of mammalian cells, pattern-recognizing components of the innate immune system.  They can be thought of as finely tuned alarm, triggering and amplifying systems that … Continue reading

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2018 meeting of the International Dose-Response Society

By Vince Giuliano As in previous years, I am posting this note regarding the forthcoming 2018 annual meeting of the International Dose-response Society.  It will be held as usual on the Campus of the University of Massachusetts in Amherst MA on April … Continue reading

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THE DOUBLE GENE KNOCKOUT BEHIND OUR OBESITY EPIDEMIC

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By James P Watson with assistance and added commentary by Vince Giuliano This is a story of how we got here to our obesity and metabolic disease epidemic.  Goes a bit back – around 30-40 million years – with another … Continue reading

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TALES OF NAD+ POWERPOINT PRESENTATION

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By Vince Giuliano Here is the PowerPoint presentation I made at the 3 rd Annual NAD Summit Conference on January 27 at 2 PM in San Diego. TALES OF NAD+  Just double click on the following link to download it. … Continue reading

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Part 2 of interventions that reduce all cause mortality (ACM) – Metformin

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by James P Watson and Vince Giuliano There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably … Continue reading

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Inflammation Part 4 – PCSK9 inhibition – Also Part 1 of interventions that reduce all cause mortality (ACM)

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By James P Watson with inputs and editorial assistance by Vince Giuliano I.  INTRODUCTION This is the fourth in what we expect will be an open-ended series of blog posts concerned with chronic inflammation.  Parts 1-6 are already published  It … Continue reading

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ON AGING

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By Vince Giuliano June 27 1017   Once in a while over the years I take a break from blog research and writing as I have done recently.  When I come back to the research and writing after such a … Continue reading

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2017 meeting of the International Dose-Response Society

Note by Vince Giuliano As in previous years, I am posting this note regarding the forthcoming 2017 annual meeting of the International Dose-response Society.  It will be held on the Campus of the University of Massachusetts in Amherst MA on April … Continue reading

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Inflammation Part 3: resolving inflammation – resolvins, protectins, maresins and lipoxins

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By Vince Giuliano This Part 3 of the Inflammation series of blog entries is concerned with the all-important resolution phase of inflammation, how acute inflammation goes away under ideal conditions instead of hunkering down to lingering and dangerous chronic inflammation. … Continue reading

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Aging, health and disease – view from the DNA Methylome

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By James P. Watson with contributions and editing by Vince Giuliano Introduction (By Vince Giuliano) Jim Watson and I have held that aging and biology, like the universe itself, have no centers.  Like the universe, they can be looked at … Continue reading

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