You probably never heard of DHMEQ but probably will he hearing a lot about it in the future.  The initials stand for dehydroxymethylepoxyquinomicin, a powerful recently-discovered inhibitor of NF-kappaB.  You might recall that the nuclear activation factor NF-kappaB plays a central role in the 13th theory of aging, Programmed Genetic Changes.  Runaway overexpression of NF-kappaB is thought to be a key factor in many maladies of old age, particularly inflammatory diseases like arthritis and cancers.  NF-kappaB is constitutively activated in the majority of cancers and is responsible, in large part, for tumor cell survival, growth and direct activation of anti-apoptotic gene factors.  DHMEQ powerfully blocks expression of NF-kappaB and a host of recent publications suggests that it might be useful as a therapeutic agent for several inflammatory diseases and cancers.  You can find some of these publications using a Google search  here.  DHMEQ is unlike some other inhibitors of NF-kappaB in that it selectively blocks translocation into the cell nucleus rather than blocking its action on specific genes.   Although all experiments to date with rodents suggest that DHMEQ is safe, to my knowledge it is not generally available today either as a supplement or as a proprietary drug.  I would not be surprised to see it becoming available in one or both of those formats soon after human safety is established.  In the interim I remind my readers that no less than 33 dietary substances in my anti-aging firewall related to programmed genetic changes are inhibitors of NF-kappaB.  Selective research studies like this one suggest that certain of the firewall NF-kappaB inhibitor substances like curcumin and resveratrol may be comparably powerful in their anti-cancer activities as DHMEQ.

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.
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