Anti-Aging Firewalls anniversary – and a thought

I published the first online version of the Anti-Aging Firewalls treatise a year ago and started this blog about six months ago.  A lot has happened on the longevity front during the period.  There have been 78 blog posts and the treatise has been updated dozens of times.  See Anti-Aging Firewalls V1.9 state of progress for a progress report as of two months ago.  The present version of the treatise is significantly expanded, corrected and far more comprehensive than the original.  Nonetheless a number of important developments have been reported in this blog and are not yet sufficiently covered in the treatise itself.  For me, it is important that the treatise at any time offers comprehensive coverage of what science knows about aging and what can be done about it.  Therefore I plan to focus my efforts during the next several days to bringing the treatise up to date.  You may not hear much from me here during that time.

I do want to share one thought from what I am writing, however.  There are the 14 theories of aging listed in the treatise and six additional candidate theories described in this blog that need to be described also in the treatise even though they don’t qualify as full aging theories yet.  They are Incorrect protein folding, Accumulation of progerin, Gene mutations leading to hellicase abnormalities, Aberrant mTOR signalling, The hypoxic response and Epigenomic changes in DNA methylation.  

Regarding these 20 theories or others that might come up, a single key theory of aging may not exist.  There are lots of biomolecular actions and genetic pathways that can lead to accelerated aging, and it appears there are also several that can delay aging at least somewhat.  Some may be more fundamental than others.  But it may well be that there is no one master theory or mechanism of aging that drives all the others.  It may be that we are looking at a large system of interacting feedback loops in which all the mechanisms of aging work together affecting each other in multiple ways.  All are primary. 

Think of a mechanical wrist watch.  It contains numerous gears, wheels, cogs and bearings.  Which is the main gear or wheel or bearing, the key component for operation of the watch?  Wrong question.  They are almost all needed.  Taking out or breaking almost any gear or cog or wheel or bearing will stop the watch or make it run screwy.  If you want a healthy functioning watch it is important that all the parts be in good shape and well-aligned with each other.  Same for us.

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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One Response to Anti-Aging Firewalls anniversary – and a thought

  1. Hi webmaster, commenters and everybody else !!! The blog was absolutely fantastic! Lots of great information and inspiration, both of which we all need!b Keep ’em coming… you all do such a great job at such Concepts… can’t tell you how much I, for one appreciate all you do!

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