2017 meeting of the International Dose-Response Society

Note by Vince Giuliano

As in previous years, I am posting this note regarding the forthcoming 2017 annual meeting of the International Dose-response Society.  It will be held on the Campus of the University of Massachusetts in Amherst MA on April 18-19. As regular readers of this blog know, my opinion is that non-linear responses at very low doses to a broad variety of stimuli is a fundamental characteristic of all biological entities at each of their multiple levels of organization In various writings I have repeatedly pointed out how this property, broadly known as hormesis, is fundamental to biology and understanding of development and aging.  It is likely to be a fundamental pillar of any emerging Grand Unified Theory of Biology. Non-linear responses to dangerous stresses, for example, trigger evolution by  an identifiable mechanism, namely transposable DNA elements (ref).  Some of the articles Jim Watson and I have produced on this hormesis phenomenon are listed here.     Suffice it to say that the International Dose-response Society is the central professional group concerned with hormesis, and the 2017 program looks at some of the highly practical and exciting applications of it.

Conference Program

The theme of the 2017 program is PRECONDITIONING IN BIOLOGY AND MEDICINE – MECHANISMS AND TRANSLATIONAL RESEARCH, which is similar to that of last year’s program.

The announcement website for the 2017 meeting including registration information can be found here.  You can download a PDF for the actual program from that site.  This year the conference will also be livestreamed for free on the Internet, but you have to register for it. Instructions for doing so are also on that site.

From the preliminary conference program: “Low levels/doses of numerous stressors (e.g., exercise, intermittent fasting, hypoxia, heat, cold, radiation, electricity, toxins, chemicals/drugs) are known to stimulate a wide range of preconditioning/adaptive responses that may profoundly affect the success of medical interventions for a vast spectrum of disorders. Stressors that trigger adaptive responses also offer ways to enhance healthy aging, improve human performance, and prevent damage in tissues exposed afterward to injurious levels of stressors, including severe psychological stress. Leading researchers will present numerous examples of the adaptive response and show how understanding molecular mechanisms(s), optimizing dosimetry and selecting the appropriate stressors will be important in enabling scientific and technological advances that can translate into future benefits for society.”

A little funny anecdote.  As a child in about 1944 I recall dialog from a “B” Western movie that went something like this:

“Doc –  Befoah you go about pullin out that bullet, we best got to give him a shot of rotgut whisky.  You know he got a bad ticker and I ain’t sure he can take it otherwise.”

 Wonder about whether there is any science behind that thought?  Giving doses of whisky before medical operations was standard-operating-procedure in all Western movies.  Well, the conference has the answer.  In Session 1 of the 2017 Dose Response conference there is a presentation entitled:  Ethanol Ingestion Elicits an Anti-inflammatory Phenotype to Limit Ischemia/Reperfusion Injury by a Neutrophil-dependent Mechanism

Areas of interest

Pre- Post-Conditioning: Alzheimer’s Disease/Dementia Parkinson’s Disease Depression and PTSD Concussions/Traumatic Brain Injury Improving Surgical Outcomes Stroke/Cardiovascular Disease Diabetes Glaucoma Stem Cell Transplantation Therapy

Healthy Lifestyles, Aging and Life Extension:Intermittent Fasting Exercise Chemical/Nutritional Supplements Low Dose Radiation and Longevity Adaptive response-based cosmetics

Enhancing Human Performance: Cognition Endurance, Strength and Speed Fatigue/Jet Lag: Prolong Onset/ Speed Up Recovery Wound Healing Acceleration – skin, tendon, muscle, bone, and vascular.”

 

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career. I have been at this part-time for well over a decade, and in 2007 this became my mainline activity. In earlier reincarnations of my career. I was founding dean of a graduate school and a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.
This entry was posted in Uncategorized. Bookmark the permalink.

2 Responses to 2017 meeting of the International Dose-Response Society

  1. HighDesertWizard says:

    Thanks Vincent for the post…

    The evidence about the effect of ethanol on Muscarinic receptors is mixed. Some studies show antagonism, others show agonism. Here’s one that shows agonism.

    Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells
    http://jpet.aspetjournals.org/content/278/1/313

    By the way, there are also a few studies that hint at various Racetam Family Nootropics also increasing Muscarinic Receptor density. Here’s one…

    Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice
    https://link.springer.com/article/10.1007%2FBF00735884?LI=true

    Best!

  2. High Desert Wizard:

    Thanks for your comment. Sorry for the delay in getting it online. I have to wade through tons of blocked spam to find valid comments. the link relating pirecetam to muscaarinic receptors is interesting because I have often wondered exactly how pirecetam works.

    Vince

Leave a Reply