It is now approximately 11 months since I posted the first version of the Anti-Aging Firewalls treatise and it is interesting to identify how the current version of the treatise (which might be considered to be Version 1.9) is different from the original one. I have been updating the treatise frequently, sometimes weekly, sometimes daily. There have been at least a dozen major upgrades and additions over the period including one made today which includes a new section on the Relationships among the theories of aging. Compared to the original, the treatise now:
· Embodies three additional theories of aging beyond the original 11 ones, Telomere Shortening and Damage, Programmed Epigenomic Changes, and Decline in Adult Stem Cell Differentiation,
· Embodies significant discussions throughout on the relationships among the theories of aging including the new section on that topic,
· Has a summary section describing the Combined Lifestyle Regimen,
· Has a revised Combined Dietary Supplement regimen with a few substances added to the original list, a deletion or two and revised dosages for a few supplements,
· Embodies considerable discussion on selected topics including stem cell differentiation, neurogenesis, telomerase-related developments and the role of NF-kappaB,
· Provides a much larger number of research literature research links backing up key points,
· Provides considerable more discussion on the roles of certain of the dietary supplements, and
· Embodies a series of technical notes on subjects like protein folding, telomerase binding proteins, and the firewall against osteoarthritis
These changes reflect two factors: first, developments reported in the research literature during the 11-month period that came to my attention, and second, continuing increase in my own awareness and comprehension. I believe the net result is improvement in the scientific integrity and comprehensiveness of the treatise. This Blog, started in January 2009, now includes some 55 major postings and is an important complement to the treatise. Specifically, I have explored certain topics here that are peripheral to the main treatise, topics like epigenomics, population longevity studies, the economics of longevity and the prospects for living very long. A complete list of postings can be found by clicking on the left on Site Admin and then on the Manage tab. You might have to be a registered user and login in order to access the entire list.