Phytochemicals – focus on caffeic acid

A large number of substances in the combined anti-aging firewalls dietary regimen such as green tea extract, ashwagandah, curcumin, resveratrol, olive leaf extract and boswellia seratta are herbal in origin and contain multiple phytochemicals that have pluripotent antiaging effects. Caffeic acid is one such phytochemical, found naturally in coffee and many fruits and herbs.  Studies  show that caffeic acid and its phenethyl ester (CAPE) have multiple positive health and anti-aging impacts.  It has anti-oxidant, anti-inflammatory and anti-bacterial capabilities.  It inhibits the growth of tumor cells and is an inhibitor of nuclear factor kappa beta (NF-kappaB)(ref,ref,ref,ref). CAPE protects brain against oxidative stress and inflammation induced by diabetes in rats(ref).   

Thus, caffeic acid is part of the Anti-Aging Firewalls against Oxidative Damage, Chronic Inflammation, Susceptibility to Cancers and Programmed Epigenomic Changes for starters. It is probably best to get caffeic acid through drinking coffee, foods and herbal supplements rather than taking it directly as a supplement, however, since some earlier studies suggest that the substance may not be completely free of side effects. In the anti-aging firewalls supplements, caffeic acid is found in green tea extract, ginger extract, olive leaf extract and curcumin.  It is also found in cayenne pepper, celery, thyme, tarragon, black tea, cucumbers, apples, potatos, radishes, cabbage, grapefruit, bell peppers and of course coffee.  List of plants containing caffeic acid can be found here and, at the bottom, here.  

Caffeic acid is only one of a large list of phytochemicals with well-researched positive health and anti-aging capabilities.  I may feature others on this blog in the future.

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 93. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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