Research evidence for the Decline In Adult Stem Cell Differentiation theory of aging.

A study published in the latest issue of the online journal Cell Stem Cell provides additional research evidence supporting the Decline in Adult Stem Cell Differentiation theory of aging, the 14th theory treated in my treatise.  This theory holds that aging is due to a slowing rate of organ regeneration due to declining somatic cell differentiation activity.  This theory states that in addition to or perhaps instead of being concerned that aging is due to cells being damaged or reaching their reproductive  limit (such as according to the Oxidative Damage or the Telomere Shortening and Damage theories  of aging), we should be concerned that cells are not being replaced by freshly minted cells created by differentiating stem cells. 

The new study report TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance  indicates that “that the p53 family member, TAp63, is essential for maintenance of epidermal and dermal precursors and that, in its absence, these precursors senesce and skin ages prematurely.” “TAp63 / mice (mice with TAp63 knocked out) age prematurely and develop blisters, skin ulcerations, senescence of hair follicle-associated dermal and epidermal cells, and decreased hair morphogenesis.” – “These data indicate that TAp63 serves to maintain adult skin stem cells by regulating cellular senescence and genomic stability, thereby preventing premature tissue aging(ref).” 

Again the message is that if you are worried about aging, be concerned with the supply chain for new somatic cells.  Start focusing on what is happening to adult stem cells. 

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 93. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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