Bacillus polyfermenticus – not just for mice

If you have pet mice suffering from colitis, the probiotic Bacillus Polyfermenticus can help them recover from it according to a 2009 study(ref).  “Mice treated with B. polyfermenticus during the non-inflammatory period of the disease had reduced rectal bleeding, their tissues were less inflamed and they gained more weight than mice that did not receive the treatment.”  This and other probiotics are likely to offer similar and additional benefits to us humans. 

“The study occurred in two phases, one involving live mice with colitis and another that looked at human intestinal cells in a test tube. The mouse study showed that B. polyfermenticus facilitated the recovery of mice from colitis. The mice showed reduced rectal bleeding, less inflamed tissue and they gained more weight than the mice that did not receive B. polyfermenticus. The study also found that the colon tissue of the treated mice had greater angiogenesis, a process that is necessary for wounds to heal. — The test tube study allowed an in-depth look at what happens at the cellular level when human intestinal microvascular endothelial cells are exposed to B. polyfermenticus. This phase found that the probiotic treatment encouraged several steps that are part of the angiogenic process, including the migration of cells and the formation of new blood vessels. — The test tube studies also uncovered how this happens. The researchers found that B. polyfermenticus increases the production of Interleukin-8 (IL-8), a substance that enhances angiogenesis. The study also found that IL-8’s receptor, CXCR2, and a cellular pathway, known as NF-κB, play a critical role in the angiogenic process(ref).”

The 2009 research report Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice concludes “Treating colonic epithelial cells with B. polyfermenticus-conditioned medium (BPCM) enhanced cell proliferation and induced the phosphoinositide 3-kinases/Akt signaling pathway, suggesting that this bacterium can promote epithelial cell proliferation. BPCM also promoted the migration of colonic epithelial cells. These data suggest that B. polyfermenticus ameliorates colonic inflammation by suppressing apoptosis and promoting epithelial cell proliferation and migration.”

Other current research as well as prior research studies also support potential health benefits of bacillus polyfermenticus.  The 2009 report The anti-cancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition concludes “These results show that B.P. inhibits tumor growth and its anti-cancer activity occurs, at least in part, through suppressing ErbB2 and ErbB3. Taken together, our study suggests that this probiotic may be clinically used as a prophylactic treatment to prevent colon cancer development.”

The 2007 research report A Probiotic Strain of Bacillus polyfermenticus Reduces DMH Induced Precancerous Lesions in F344 Male Rat  states “In this study, we have assessed the effects of B. polyfermenticus on the antioxidant system and the process of colon carcinogenesis in male F344 rats. — These data indicate that B. polyfermenticus exerts a protective effect on the antioxidant system and the process of colon carcinogenesis, thereby suppressing the development of preneoplastic lesions.”

The 2006  report Dietary Supplementation of Probiotic Bacillus polyfermenticus, Bispan Strain, Modulates Natural Killer Cell and T Cell Subset Populations and Immunoglobulin G Levels in Human Subjects concludes “This study suggests that the supplementation of B. polyfermenticus has a potentially positive effect on immune function by enhancing IgG production as well as by modulating the number of immune cell population such as CD4+ and CD8+ T cells and NK cells.”

Other research reports indicating benefits of probiotics include M1198 Lactobacillus Rhamnosus GG Prevents Radiation Induced-Small Intestinal Injury in a MyD88 Independent, But COX2 Dependent Manner, M1199 Counterbalancing Dysbiosis in Crohn’s Disease: Faecalibacterium Prausnitzii, a Major Commensal Bacterium, Exhibits In Vitro and In Vivo Anti-Inflammatory Effects,   and M1200 Probiotic E. coli (Symbioflor®2) Treatment Mediates Antimicrobial β-Defensin (HBD-2) Synthesis and Fecal Excretion in Humans.

Here is where I have to admit a slip-up.  For nearly two years now my personal supplement regimen has included a morning multi-strain probiotic capsule.  However, somehow I have not included that supplement in my anti-aging firewalls Supplement Regimen.  I will add it in when I do my next update of the treatise, probably within 24 hours. Based on the above-cited research I am also looking for probiotic capsules which contain B. polyfermenticus, a microbe that appears not to be included in most mainline commercial US probiotic products. 

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 93. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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5 Responses to Bacillus polyfermenticus – not just for mice

  1. jeg3 says:

    In your personal regimen do you also take vitamin k and other micronutrients, since all the micronutrients seem to be important, Bruce Ames points out that being deficient in an essential nutrient can have a cascading effect even if the other nutrients are satisfactory:

    Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage
    Bruce N. Ames*

    Longevity Health Sciences: The Phoenix Conference
    Which details optimal levels of vitamins

    I definitely need to do what you did by tabulizing what I take, how much and why, and get blood testing of micronutrient levels.

  2. admin says:

    Hi jeg3

    I do take Vitamin K2 and a number of other micronutrients, although of course I am not sure I have all neessary bases covered. I do agree with what Bruce Ames says and I will read the references you provide. I might get back to you again after that.


  3. admin says:


    I am in the process of carefully reading the Bruce Ames paper on micronutrients. I am excited by it because: 1. It provides yet-another theory of aging beyond the 14 covered in my treatise, namely that aging-related degeneration and damage can result from triage allocation of micronutrients, and 2. the paper provides a justification for taking the long-long list of supplements suggested in my treatise. It answers the question I often hear “Why do you have to take so many supplements?” I think my supplement regimen has all the micronutrients mentioned in the Ames paper suggested in adequate quantities, but I have to double-check that. And this list is identical with my personal supplement regimen.

    I plan to generte a blog entry on the above. And I will first read the other two citations as well. Again, thanks for pointing them out.


  4. MJA says:

    So where in the world do I obtain this probiotic strain? I have ulcerative colitis and it’s maddening to read these studies and then find no commercial version via Google.

  5. admin says:

    Your quiestion about Bacillus Polyfermenticus is an excellent one. I too have found no commercial version so far. No doubt, one of the supplement companies will eventually get the word and make it available. Hey, readers working in companies of this kind, can you help us out please?

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