Sarcopenia – the Age-related Loss of Muscle Mass and Function – Part I: Pathways and factors

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By Victor, with contributions by Vince Giuliano Satellites in Muscle Part I It is well established that the maintenance of skeletal muscle mass contributes significantly to disease prevention and avoidance of falls and many other problems that degrade quality of … Continue reading

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Mitochondria Part 2: Mitochondrial Responses to Stress: Mitochondrial Signaling: Survival and Death Pathways

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Written by James Watson, with major contributions by Vince Giuliano Introduction – Mitochondrial Roles in the Cell This is the second part in a series of blog entries examining the roles of mitochondria in key biological activities.  For additional background … Continue reading

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Microtubules, the intra-cellular transport system, health and longevity

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Microtubules, the intra-cellular transport system, health and longevity By Vince Giuliano Image source Microtubules play important and ever-changing structural roles in cells, play key roles in  embryo development and cell division, are the basis for the intra-cellular molecular transport system, … Continue reading

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Multifactorial hormesis – the theory and practice of maintaining health and longevity

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By Vince Giuliano and James P Watson This blog entry generalizes on the concept of hormesis, discusses the multiple pathways through which hormesis takes place, and suggests a myriad of ways that ordinary people can take advantage of hormesis to … Continue reading

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Mitochondria in health and aging, and possibilities for life prolongation – Part 1:basics

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Written by Vince Giuliano, with major contributions by James P Watson This is the first of a series of blog entries examining the roles of mitochondria in key biological activities.  The goal of the series is to shed light on … Continue reading

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Buckyballs, health and longevity – state of knowledge

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By Vince Giuliano   Image source The popular “life extension” blogs have been lit up recently with exchanges related to a recent publication that reports that a homogenized solution of olive oil and C60 carbon buckyballs fed to middle age rats … Continue reading

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Plant polyphenols – six epigenetic knockout punches against cancers

Certain plant polyphenols not only exercise general positive health effects but also inhibit oncogenic transformation or the proliferation of cancer cells.  Or, they outright kill cancer cells.  Included are a substantial number of cancer-fighting plant polyphenols, some of which are … Continue reading

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The Hormetic Wild Animal “Zoo” and Their “Zookeepers”

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By James P Watson There are 2 “Mantras” Here in the Zoo – Hormesis and Nrf2 inducible Isoforms Preface – By Vince Giuliano I want to introduce and welcome James P Watson as a senior researcher and writer for this … Continue reading

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Editorial -Bridging the Great Divide

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     By Vince Giuliano There appears to be a Great Divide in the world when it comes to health, manifest most clearly in Western Countries and in the US in particular.  The divide is between two major paradigms of … Continue reading

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Mitohormesis

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By Vince Giuliano This blog is about Mitohormesis, a different form of hormesis than that discussed in the previous blog entry Radiation Hormesis.  Mitohormesis has to do with cell metabolic pathways and oxidative stress, topics I have discussed in many … Continue reading

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