30 Major Factors that Control SIRT1 Expression, SIRT1 Activity, and SIRT1-mediated Aging. Part 3 of the series NAD+ an emerging framework for health and life extension

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  By James P Watson with comments and editorial assistance by Vince Giuliano Introduction by Vince Giuliano: This is the third blog entry in the series NAD+ an emerging framework for health and life extension.  The first two entries were  … Continue reading

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A simple, comprehensive plan to prevent or reverse Alzheimer’s Disease and other neurodegenerative diseases – Part 1: The Plan

By James P Watson, with contributions and editorial assistance by Vince Giuliano  INTRODUCTION AND OVERALL PRINCIPLES This is the first of a pair of blog entries concerned with dementias – neurological diseases including Alzheimer’s Disease (AD) and its cousins.  This … Continue reading

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Digital health – health and fitness wearables, Part 3: Heart Rate Variability: Principles and Science and Practical Measuring Devices

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By James P Watson with contributions and editorial assistance by Vince Giuliano This is the third blog entry related to electronic wearable devices capable of making personal behavioral and physical parameter measurements that bear on health and wellness and likely … Continue reading

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Digital health – health and fitness wearables, Part 2: looking for practical stress biomarkers

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By Vince Giuliano This entry is different from any other published so far in this blog  – it describes an original research experiment rather than characterizing a whole area of research or being an editorial. This is the second blog … Continue reading

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Digital health – health and fitness wearables, apps and platforms – implications for assessing health and longevity interventions – Part 1 Flux in the market

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By Vince Giuliano with inputs and assistance from Melody Winnig and James P Watson INTRODUCTION The consumer electronics industry is giving a tremendous boost to public and individual health – perhaps the most important boost in the first half of … Continue reading

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NAD+ an emerging framework for life health and life extension — Part 2: Deeper into the NAD World, hopeful interventions

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By James P Watson with contributions and assistance by Vince Giuliano This is Part 2 of what will likely be a three or four-part series of blog entries related to the metabolic cofactor NAD+. The  Part 1 blog entry provided … Continue reading

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NAD+ an emerging framework for health and life extension — Part 1: The NAD World

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By Vince Giuliano with inputs from  James P. Watson Accelerated by the publication in December 2013 of a seminal paper by David Sinclair and his US and Australian colleagues(ref), there has been increasing interest and excitement about the prospects of … Continue reading

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The Prospects that Emerging Science Offers Us for Long Healthy Lifespans – PowerPoint presentation for non-scientists

By Vince Giuliano I rarely hesitate to talk about exciting research developments reported in this blog with my friends.  However, only a few people  in our local community of Wayland Massachusetts have known about the blog or our work on … Continue reading

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The Alpha and Beta of GSK-3s – first in the Strange but Powerful Molecules Series

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The Molecules that Play Dr. Jeckel and Mr. Hyde in Aging, Alzheimer’s Disease, and Type II Diabetes By James P Watson, with summary and contributions from Vince Giuliano Introduction – GSK-3s – The “Dr. Jeckel and Mr. Hyde” Molecules Have … Continue reading

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Prospectus for reversing age-related immune senescence

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By Vince Giuliano and Jim Watson Immune  system functionality declines significantly with advancing age, leading to increased susceptibility to infectious and many other diseases.  This is a very important aspect of aging as we know it.  This blog entry looks … Continue reading

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