Hutchinson-Gilford Progeria Syndrome – a disease of accelerated aging due to Alternative Splicing

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By James P Watson with editorial assistance and contributions from Vince Giuliano I.  WHY YOU SHOULD BE INTERESTED IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) Summary: HGPS is a major clue to solving the “puzzle of aging” and the molecular mechanisms here … Continue reading

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Transposable DNA elements – Part 3 TEs and and other key mechanisms of evolution: incRNAs, A to I editing, alternative splicing and exonization

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By Vince Giuliano, with inspiration by Jim Watson                   Image source:  “These clusters of cells are 1 billion years old, the oldest to appear in freshwater/land ecosysems   Credit: Oxford University/Martin Brasier ”  … Continue reading

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Transposable DNA elements –- Part 2: The Self-copy Machines in Your Genes

By James P Watson with editorial and some content contribution by Vince Giuliano This is the second blog entry in a three-part series concerned with transposable DNA entries (TEs).  The Part 1 entry focused on basics of what TEs are, … Continue reading

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Transposable DNA elements – Part 1: basics and importance

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By Vince Giuliano, inspired by interaction by James P. Watson This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs).  It focuses on basics of what TEs are, why they are important for us … Continue reading

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G-qaudruplexes

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By James P Watson with editorial help and selected contributions by Vince Giuliano Image source Human telomeric G-quadruplex structure  Introduction by Vince Giuliano If you are new to G-quadraplexes, I can appreciate reader resistance to confronting the intellectual challenge of … Continue reading

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The top 21Benefits of Meditation

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By James P Watson, with editorial assistance and comments by Vince Giuliano and Melody Winnig Initial  comments – by Vince Giuliano This blog entry is about thoroughly documented health and possible longevity benefits of meditation, quite apart from possible spiritual … Continue reading

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Digital Health Part 4: Heart rate stress biomarkers derivable from smart watch data

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  By Vince Giuliano This blog entry focuses deeper on personal research I have been doing on specific constitutional stress biomarkers derivable from measurements by a smart watch, a Basic Peak in my case.  I described the stress biomarkers and … Continue reading

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Part 4 of the NAD world: the NQ01 gene, the Warburg effect, SIRT 1 and inflammation, and possible interventions

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By James P Watson with contributions and editorial assistance by Vince Giuliano This Part 4 blog entry goes even further into the extended NAD story, examining important subtopics: The ratio NAD+/NADH in cells and the body, which may be as … Continue reading

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30 Major Factors that Control SIRT1 Expression, SIRT1 Activity, and SIRT1-mediated Aging. Part 3 of the series NAD+ an emerging framework for health and life extension

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  By James P Watson with comments and editorial assistance by Vince Giuliano Introduction by Vince Giuliano: This is the third blog entry in the series NAD+ an emerging framework for health and life extension.  The first two entries were  … Continue reading

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A simple, comprehensive plan to prevent or reverse Alzheimer’s Disease and other neurodegenerative diseases – Part 1: The Plan

By James P Watson, with contributions and editorial assistance by Vince Giuliano  INTRODUCTION AND OVERALL PRINCIPLES This is the first of a pair of blog entries concerned with dementias – neurological diseases including Alzheimer’s Disease (AD) and its cousins.  This … Continue reading

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