AGING, CELL AND TISSUE REPAIR, RENEWAL AND REGENERATION, INFLAMMATION AND THE SASP

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By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have … Continue reading

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Inflammation Part 5: Inflammasomes – science of and disease implications

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By James P. Watson and Vince Giuliano Inflammasomes are multimeric self-assembling protein complexes within the cytosol of mammalian cells, pattern-recognizing components of the innate immune system.  They can be thought of as finely tuned alarm, triggering and amplifying systems that … Continue reading

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2018 meeting of the International Dose-Response Society

By Vince Giuliano As in previous years, I am posting this note regarding the forthcoming 2018 annual meeting of the International Dose-response Society.  It will be held as usual on the Campus of the University of Massachusetts in Amherst MA on April … Continue reading

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THE DOUBLE GENE KNOCKOUT BEHIND OUR OBESITY EPIDEMIC

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By James P Watson with assistance and added commentary by Vince Giuliano This is a story of how we got here to our obesity and metabolic disease epidemic.  Goes a bit back – around 30-40 million years – with another … Continue reading

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TALES OF NAD+ POWERPOINT PRESENTATION

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By Vince Giuliano Here is the PowerPoint presentation I made at the 3 rd Annual NAD Summit Conference on January 27 at 2 PM in San Diego. TALES OF NAD+  Just double click on the following link to download it. … Continue reading

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Part 2 of interventions that reduce all cause mortality (ACM) – Metformin

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by James P Watson and Vince Giuliano There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably … Continue reading

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Inflammation Part 4 – PCSK9 inhibition – Also Part 1 of interventions that reduce all cause mortality (ACM)

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By James P Watson with inputs and editorial assistance by Vince Giuliano I.  INTRODUCTION This is the fourth in what we expect will be seven or more blog posts concerned with chronic inflammation.  It relates to a recently discovered protein … Continue reading

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ON AGING

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By Vince Giuliano June 27 1017   Once in a while over the years I take a break from blog research and writing as I have done recently.  When I come back to the research and writing after such a … Continue reading

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2017 meeting of the International Dose-Response Society

Note by Vince Giuliano As in previous years, I am posting this note regarding the forthcoming 2017 annual meeting of the International Dose-response Society.  It will be held on the Campus of the University of Massachusetts in Amherst MA on April … Continue reading

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Inflammation Part 3: resolving inflammation – resolvins, protectins, maresins and lipoxins

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By Vince Giuliano This Part 3 of the Inflammation series of blog entries is concerned with the all-important resolution phase of inflammation, how acute inflammation goes away under ideal conditions instead of hunkering down to lingering and dangerous chronic inflammation. … Continue reading

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