Oxidative damage – cause or effect?

A reported study about free radicals is radical in its conclusions.  The study was based on disabling five genes in mutant Caenorhabditis elegans worms.  The study’s authors suggest that damage due to free radicals may not be a cause of aging but rather is a consequence of aging and suggest instead that the aging process may originate in the mitochondria.  See my discussion on the Mitochondrial DNA mutation theory of aging.  It would seriously upset the anti-aging establishment’s applecart if oxidative damage turned out to be only a symptom.  However, I hesitate to accept such a broad conclusion given the preponderance of evidence that exposure to strong oxidative stress, such as massive doses of radiation, generates the overt symptoms of aging.  Most likely we are dealing with a chicken-and-egg causative process here where it is both the case that oxidative damage contributes to aging and that aging contributes to oxidative damage.  And the mitochondria play an important role in mediating the aging process.  See the previous blog post as well.

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 93. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at www.vincegiuliano.com and an extensive site of my art at www.giulianoart.com. Please note that I have recently changed my mailbox to vegiuliano@agingsciences.com.
This entry was posted in Uncategorized. Bookmark the permalink.

One Response to Oxidative damage – cause or effect?

  1. Pingback: The free radical theory of aging. Is it really a theory of aging? | AGING SCIENCES – Anti-Aging Firewalls

Leave a Reply