Telomerase activation – upside and downside

First of all, today I updated the discussion related to the Telomere Shortening and Damage theory of aging. The treatise now has a more comprehensive and up-to-date discussion of the topic with more literature citations.  Not a lot new is included for regular readers of this blog, however. 

Second, a personal item.  Since switching to the 100mg dose of astragaloside IV a couple of months ago I have reported continuing to experience wellbeing and more and more hairs appearing on my previously-bald scalp.  Yesterday I found out another thing.  A biopsy report indicated that a rapidly-growing growth removed from my armpit was a basal-cell carcinoma.  I had had a couple of such small carcinomas removed some 5 years ago but they stopped developing then  when I increased my resveratrol, curcumin and aswagandha supplements to their current levels.  The growth was easily removed and in no-way was life-threatening.  However, I found out that my current “firewall against cancers” is not now bulletproof.

One possibility is that the skin cancer development was correlated with the increased dosage of astragaloside IV.  As you may have noted in my recent post On Cancer Stem Cells, more and more researchers are looking to cancer stem cells as being the key targets for anti-cancer therapy rather than mature cancer cells.  Enhanced expression of telomerase, as I have pointed out, increases differentiation and proliferation of normal stem cells through a pathway independent of telomere extension.  There are hints in the research literature that telomerase activation may be doing the same for cancer stem cells.  I will be seeing what I can turn up in the research literature relevant to this.  And I may suggest shifts in my anti-cancer firewall regimen for people taking telomerase activators.

About Vince Giuliano

Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. That is, I personally practice the anti-aging interventions that I preach and that has kept me healthy, young, active and highly involved at my age, now 93. I am as productive as I was at age 45. I don’t know of anybody else active in that community in my age bracket. In particular, I have focused on the importance of controlling chronic inflammation for healthy aging, and have written a number of articles on that subject in this blog. In 2014, I created a dietary supplement to further this objective. In 2019, two family colleagues and I started up Synergy Bioherbals, a dietary supplement company that is now selling this product. In earlier reincarnations of my career. I was Founding Dean of a graduate school and a full University Professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and C00 of Mirror Systems, a software company, and an international Internet consultant. I got off the ground with one of the earliest PhD's from Harvard in a field later to become known as computer science. Because there was no academic field of computer science at the time, to get through I had to qualify myself in hard sciences, so my studies focused heavily on quantum physics. In various ways I contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s. I am now engaged in doing the same for The Longevity Revolution. I have published something like 200 books and papers as well as over 430 substantive.entries in this blog, and have enjoyed various periods of notoriety. If you do a Google search on Vincent E. Giuliano, most if not all of the entries on the first few pages that come up will be ones relating to me. I have a general writings site at and an extensive site of my art at Please note that I have recently changed my mailbox to
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