Blog Archives

Part 2 of interventions that reduce all cause mortality (ACM) – Metformin

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by James P Watson and Vince Giuliano There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably … Continue reading

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Inflammation Part 4 – PCSK9 inhibition – Also Part 1 of interventions that reduce all cause mortality (ACM)

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By James P Watson with inputs and editorial assistance by Vince Giuliano I.  INTRODUCTION This is the fourth in what we expect will be seven or more blog posts concerned with chronic inflammation.  It relates to a recently discovered protein … Continue reading

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ON AGING

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By Vince Giuliano June 27 1017   Once in a while over the years I take a break from blog research and writing as I have done recently.  When I come back to the research and writing after such a … Continue reading

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2017 meeting of the International Dose-Response Society

Note by Vince Giuliano As in previous years, I am posting this note regarding the forthcoming 2017 annual meeting of the International Dose-response Society.  It will be held on the Campus of the University of Massachusetts in Amherst MA on April … Continue reading

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Inflammation Part 3: resolving inflammation – resolvins, protectins, maresins and lipoxins

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By Vince Giuliano This Part 3 of the Inflammation series of blog entries is concerned with the all-important resolution phase of inflammation, how acute inflammation goes away under ideal conditions instead of hunkering down to lingering and dangerous chronic inflammation. … Continue reading

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Aging, health and disease – view from the DNA Methylome

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By James P. Watson with contributions and editing by Vince Giuliano Introduction (By Vince Giuliano) Jim Watson and I have held that aging and biology, like the universe itself, have no centers.  Like the universe, they can be looked at … Continue reading

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Presentation videos – The Science and Technology of Longevity

By Vince Giuliano On Thursday June16, 2016, I offered a pair of talks on The Science and Technology of Longevity at a meeting hosted by the Silicon Valley Health Institute  in Palo Alto California. The talks were recorded and you can access them here at your convenience … Continue reading

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Part 5 of the NAD world: the conflicting roles of NAMPT – inflammation or rescue? Also Part 1 on a new series on inflammation

By James P Watson with commentary and assistance by Vince Giuliano Introduction by Vince Giuliano This blog entry relates another important story of what goes on in the NAD world. This is also the first entry of what I expect … Continue reading

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Coming in this blog

By Vince Giuliano and James P Watson This entry signals some intended changes in our blogging approach and lists some blog entries we plan to publish soon. A.  Changes in blogging approach We expect to go to shorter more- focused … Continue reading

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2016 meeting of the International Dose-response Society

Note by Vince Giuliano As has been the case in several previous years, I intend to attend the 2016 annual meeting of the International Dose-response Society which will be held on the Campus of the University of Massachusetts in Amherst … Continue reading

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