Author Archives: James Watson

About James Watson

I am a physician with a keen interest in the molecular biology of aging. I have specific interests in the theories of antagonistic pleiotropy and hormesis as frameworks to understand cellular senescence and mechanisms for coping with cellular stress. The hormetic "stressors" that I am interested in exploiting at low doses include exercise, hypoxia, intermittent caloric restriction, radiation, etc. I also have a very strong interest in the epigenetic theory of aging and pharmacologic/dietary maintenance of histone acetylation and DNA methylation with age. I also am working on pharmacologic methods to destroy senescent cells and to reactivate quiescent endogenous stem cells. In cases where there is a "stem cell exhaustion" in the specific niche, I am very interested in stem cell therapy (Ex: OA)

ACE and Angiotensin II: The “Double Agents” that Play Multiple Roles in the Molecular Story of Life

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By James P Watson, with editorial assist, a little rounding out and a few comments by Vince Giuliano Image source I am convinced that actions in the Renin-Angiotensin cascade can be a major cause of inflammation, aging, and cancer.  Exogenous antioxidants, … Continue reading

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Nuts over Nuts

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By James P. Watson, with help and some additions by Vince Giuliano Introduction  Nuts have long been “labeled” as a bad source of nutrition due to their high fat content.  However, a growing body of scientific studies have shown that … Continue reading

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Genetic and epigenetic factors in cancer, cellular senescence and the light and dark sides of exosome communications in cancer

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By James P Watson with assistance by Vince Giuliano This blog entry looks at the genetic and epigenetic factors in cancer.  The news here is basically good – epigenetic transformations seem in many cases to be upstream of genetic mutations … Continue reading

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Circular RNA – The RNA Story is coming Full Circle” – “Exon Skipping”explains Atherosclerosis and possibly aging

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By James P Watson with contributions and editing by Vince Giuliano This blog entry tells two stories.  The first story is that of circular RNAs.  Once we thought that any important DNA was located in the nucleus of cells on … Continue reading

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More on the xenohormetic live food hypothesis – synergies among polyphenols, additional post-harvest plant stressors and stress responses, plant polyphenol transcription factors, and more

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By James P Watson  I believe the the message of the previous blog entry Health through stressing fruits and vegetables – the Xenohormetic Live Food Hypothesis by Vince and Melody is worthy of acclaim.  As so frequently happens, it fueled … Continue reading

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THE HORMESIS BARS

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A collection of stories and explanations by Jim Watson and Vince Giuliano The stories are fantasies about new kinds of bars that could possibly exist in the future.  The Hormesis Bars are ones where all the drinks produce stresses.  According … Continue reading

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PART 3: Slaying Two Dragons with the Sound of Silence: – How to Keep Your Repetitive DNA Turned Off with “3 Songs”: Sirtuins, Polycomb Proteins, and DNMT3. And a Master List of Drugs and Natural Compounds for Cancer Chemoprevention

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By James Watson (with some help from Vince Giuliano) Image source This is the Part 3 of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slowed … Continue reading

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PART 2: Slaying Two Dragons with One Hail of Stones: The Silencing Of Good Genes In Aging And Cancer – And How Polyphenols Can Prevent That

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 By James Watson (with editorial help from Vince Giuliano) Image source This is the Part 2 of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slowed … Continue reading

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Autophagy – the housekeeper in every cell that fights aging

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By James P Watson and Vince Giuliano Background and introduction There is a wide variety of genetic manipulations, pharmacologic manipulations, and nutrient manipulations that have been shown to alter lifespan in model organisms.  These include caloric restriction, “loss of function” … Continue reading

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Mitochondria Part 2: Mitochondrial Responses to Stress: Mitochondrial Signaling: Survival and Death Pathways

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Written by James Watson, with major contributions by Vince Giuliano Introduction – Mitochondrial Roles in the Cell This is the second part in a series of blog entries examining the roles of mitochondria in key biological activities.  For additional background … Continue reading

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