Search Results for: histone methylation

DEEPER INTO THE EPIGENETICS OF YOUNGING 1.1 — INTERACTIONS OF H3K9, H3K4, H3K27, H3K79 AND BIVALENT HISTONE POST-TRANSLATIONAL MODIFICATION (PMT) DOMAINS

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By Vince Giuliano.  With contributions, suggestions and editing by members of the YOUNGING team: Steve Buss, Walter Crompton, Chris Wikman and Debbie Coehlo 5-1-2022 GENERAL CONTEXT From the onset some 12 years ago, this anti-agingfirewalls blog has followed an implicit Mission … Continue reading

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DNA demethylation – a new way of coming at cancers

I got into this topic indirectly, starting out by researching what is known about DNA demethylation in response to a comment by Res on my blog post Homicide by DNA methylation.  I found a great deal of interesting material related … Continue reading

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Histone acetylase and deacetylase inhibitors

Readers, please don’t turn off on this post because the subject sounds too technical.  It relates to a major application area of epigenomics that has a lot to do with aging and anti-aging science. First, a simplified review of a … Continue reading

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DNA methylation, personalized medicine and longevity

We as people are very different from each other.  And a medicine that may work well on one person may not work well on another or even poison him.  The dream of personalized  medicine is that your genetic and epigenetic … Continue reading

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YGC MORE ON YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY

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I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via  JMJD2/JMJD3.  I go deeper into the biology and processes of histone methylation – and relate these to longevity and YOUNGING01. Continue reading

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Unlocking Longevity

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By Vince Giuliano 9-27 -2023 Preface and a personal note In April of this year, I experienced a breakthrough in understanding human aging.  This was a key event for me, coming after 15 years of full-time study and writing 600 … Continue reading

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Healthy, active and productive till 100. Laying out the Adult Aging Process, a Breakthrough and my Personal Story

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By Vince Giuliano The causal chain of events leading to advanced human aging has only been clarified very recently.  A key step in this causal chain is systemic inflammation leading to accelerated epigenetic aging.  In reports of other researcher and … Continue reading

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Two faces of Life Extension

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By Vince Giuliano There are two distinct faces of life extension which are often confused, even by the best researchers working in the longevity field.  This sometimes leads to paradoxical observations.  I seek to clarify what these faces are in … Continue reading

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YGE YOUNGING 1.0 PART 5: PRACTICAL INITIATION OF YOUNGING 1.0 VIA HYPOXIC INTERVENTIONS

By Vince Giuliano and Steve Buss  Image source – retinal neuron This is the fifth blog entry on a natural process of aging in reverse we have called YOUNGING 1.0.  It is about a category of practical interventions that humans … Continue reading

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YGD YOUNGING1.0 PART 4: UNDERLYING MECHANISMS OF YOUNGING 1.0. HSC STEM CELL DIFFERENTIATION

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By Vince Giuliano Art KOUKOU by Vince Giuliano I.   INTRODUCTION AND BACKGROUND YOUNGING processes in the human body are like AGING processes in reverse. I have suggested that there are natural YOUNGING processes normally going on in mature humans, along … Continue reading

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