Search Results for: DNA methylation

Homicide by DNA methylation

A recent publication suggests that DNA methylation may be the cause of aging and death in higher organisms.  The May 2009 publication by Alexander L. Mazin from Lomonosov Moscow State University is entitled Suicidal function of DNA methylation in age-related … Continue reading

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DNA methylation, personalized medicine and longevity

We as people are very different from each other.  And a medicine that may work well on one person may not work well on another or even poison him.  The dream of personalized  medicine is that your genetic and epigenetic … Continue reading

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DNA demethylation – a new way of coming at cancers

I got into this topic indirectly, starting out by researching what is known about DNA demethylation in response to a comment by Res on my blog post Homicide by DNA methylation.  I found a great deal of interesting material related … Continue reading

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Aging, health and disease – view from the DNA Methylome

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By James P. Watson with contributions and editing by Vince Giuliano Introduction (By Vince Giuliano) Jim Watson and I have held that aging and biology, like the universe itself, have no centers.  Like the universe, they can be looked at … Continue reading

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Transposable DNA elements – Part 3 TEs and and other key mechanisms of evolution: incRNAs, A to I editing, alternative splicing and exonization

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By Vince Giuliano, with inspiration by Jim Watson                   Image source:  “These clusters of cells are 1 billion years old, the oldest to appear in freshwater/land ecosysems   Credit: Oxford University/Martin Brasier ”  … Continue reading

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Transposable DNA elements –- Part 2: The Self-copy Machines in Your Genes

By James P Watson with editorial and some content contribution by Vince Giuliano This is the second blog entry in a three-part series concerned with transposable DNA entries (TEs).  The Part 1 entry focused on basics of what TEs are, … Continue reading

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Transposable DNA elements – Part 1: basics and importance

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By Vince Giuliano, inspired by interaction by James P. Watson This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs).  It focuses on basics of what TEs are, why they are important for us … Continue reading

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PART 3: Slaying Two Dragons with the Sound of Silence: – How to Keep Your Repetitive DNA Turned Off with “3 Songs”: Sirtuins, Polycomb Proteins, and DNMT3. And a Master List of Drugs and Natural Compounds for Cancer Chemoprevention

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By James Watson (with some help from Vince Giuliano) Image source This is the Part 3 of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slowed … Continue reading

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DNA Methyltransferases, stem cell proliferation and differentiation

Perhaps the two most comprehensive theories explaining aging in my treatise are Programmed Epigenomic Changes and Stem Cell Supply Chain Breakdown.  Recent research related to the epigenetics of stem cells deals with the profound underlying relationships between those two theories.  … Continue reading

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AGING, CELL AND TISSUE REPAIR, RENEWAL AND REGENERATION, INFLAMMATION AND THE SASP

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By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have … Continue reading

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