A recent publication suggests that DNA methylation may be the cause of aging and death in higher organisms. The May 2009 publication by Alexander L. Mazin from Lomonosov Moscow State University is entitled Suicidal function of DNA methylation in age-related … Continue reading
We as people are very different from each other. And a medicine that may work well on one person may not work well on another or even poison him. The dream of personalized medicine is that your genetic and epigenetic … Continue reading
I got into this topic indirectly, starting out by researching what is known about DNA demethylation in response to a comment by Res on my blog post Homicide by DNA methylation. I found a great deal of interesting material related … Continue reading
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By James P. Watson with contributions and editing by Vince Giuliano Introduction (By Vince Giuliano) Jim Watson and I have held that aging and biology, like the universe itself, have no centers. Like the universe, they can be looked at … Continue reading
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By Vince Giuliano, with inspiration by Jim Watson Image source: “These clusters of cells are 1 billion years old, the oldest to appear in freshwater/land ecosysems Credit: Oxford University/Martin Brasier ” … Continue reading
By James P Watson with editorial and some content contribution by Vince Giuliano This is the second blog entry in a three-part series concerned with transposable DNA entries (TEs). The Part 1 entry focused on basics of what TEs are, … Continue reading
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By Vince Giuliano, inspired by interaction by James P. Watson This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us … Continue reading
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By James Watson (with some help from Vince Giuliano) Image source This is the Part 3 of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slowed … Continue reading
Perhaps the two most comprehensive theories explaining aging in my treatise are Programmed Epigenomic Changes and Stem Cell Supply Chain Breakdown. Recent research related to the epigenetics of stem cells deals with the profound underlying relationships between those two theories. … Continue reading
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I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – and relate these to longevity and YOUNGING01. Continue reading