Author Archives: James Watson

About James Watson

I am a physician with a keen interest in the molecular biology of aging. I have specific interests in the theories of antagonistic pleiotropy and hormesis as frameworks to understand cellular senescence and mechanisms for coping with cellular stress. The hormetic "stressors" that I am interested in exploiting at low doses include exercise, hypoxia, intermittent caloric restriction, radiation, etc. I also have a very strong interest in the epigenetic theory of aging and pharmacologic/dietary maintenance of histone acetylation and DNA methylation with age. I also am working on pharmacologic methods to destroy senescent cells and to reactivate quiescent endogenous stem cells. In cases where there is a "stem cell exhaustion" in the specific niche, I am very interested in stem cell therapy (Ex: OA)

Part 4 of the NAD world: the NQ01 gene, the Warburg effect, SIRT 1 and inflammation, and possible interventions

This gallery contains 12 photos.

By James P Watson with contributions and editorial assistance by Vince Giuliano This Part 4 blog entry goes even further into the extended NAD story, examining important subtopics: The ratio NAD+/NADH in cells and the body, which may be as … Continue reading

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30 Major Factors that Control SIRT1 Expression, SIRT1 Activity, and SIRT1-mediated Aging. Part 3 of the series NAD+ an emerging framework for health and life extension

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  By James P Watson with comments and editorial assistance by Vince Giuliano Introduction by Vince Giuliano: This is the third blog entry in the series NAD+ an emerging framework for health and life extension.  The first two entries were  … Continue reading

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A simple, comprehensive plan to prevent or reverse Alzheimer’s Disease and other neurodegenerative diseases – Part 1: The Plan

By James P Watson, with contributions and editorial assistance by Vince Giuliano  INTRODUCTION AND OVERALL PRINCIPLES This is the first of a pair of blog entries concerned with dementias – neurological diseases including Alzheimer’s Disease (AD) and its cousins.  This … Continue reading

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Digital health – health and fitness wearables, Part 3: Heart Rate Variability: Principles and Science and Practical Measuring Devices

This gallery contains 8 photos.

By James P Watson with contributions and editorial assistance by Vince Giuliano This is the third blog entry related to electronic wearable devices capable of making personal behavioral and physical parameter measurements that bear on health and wellness and likely … Continue reading

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NAD+ an emerging framework for life health and life extension — Part 2: Deeper into the NAD World, hopeful interventions

This gallery contains 27 photos.

By James P Watson with contributions and assistance by Vince Giuliano This is Part 2 of what will likely be a six-part series of blog entries related to the metabolic cofactor NAD+ and what goes on in the NAD World,  … Continue reading

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The Alpha and Beta of GSK-3s – first in the Strange but Powerful Molecules Series

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The Molecules that Play Dr. Jeckel and Mr. Hyde in Aging, Alzheimer’s Disease, and Type II Diabetes By James P Watson, with summary and contributions from Vince Giuliano Introduction – GSK-3s – The “Dr. Jeckel and Mr. Hyde” Molecules Have … Continue reading

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The Amyloid Beta face of Alzheimer’s Disease

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By Jim Watson with editorial and minor contributions by Vince Giuliano Much has been learned over the years about Alzheimer’s Disease (AD) and there are several sides to the unfolding story which considered together are making more and more sense.  … Continue reading

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Nuclear Aging: The View from the Telomere end of the Chromosome – Part 2 – Telomere Molecular Biology

This gallery contains 11 photos.

By James P Watson with editorial assistance and a few comments by Vince Giuliano This is Part 2 of 3 in the series The View from the Telomere end of the Chromsome.  Because of the length of the extended telomere story, we … Continue reading

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Nuclear Aging: The View from the Telomere end of the Chromosome Part 1 – context, history, and about telomere lengths

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By James P Watson with Preface and editorial assistance by Vince Giuliano Preface by Vince Giuliano According to the latest theories of cosmology, the universe has no center.  However, anyplace in the universe, including where we are on Earth, can … Continue reading

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Jim Watson’s “Top 12” List of “Things I Learned about Aging” in 2013

By James P Watson with editorial assistance from Vince Giuliano In the style of David Letterman’s “top 10 list” from late night TV, I am listing my own list of the most important things that I personally learned in 2013 … Continue reading

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