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30 Major Factors that Control SIRT1 Expression, SIRT1 Activity, and SIRT1-mediated Aging. Part 3 of the series NAD+ an emerging framework for health and life extension

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  By James P Watson with comments and editorial assistance by Vince Giuliano Introduction by Vince Giuliano: This is the third blog entry in the series NAD+ an emerging framework for health and life extension.  The first two entries were  … Continue reading

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NAD+ an emerging framework for life health and life extension — Part 2: Deeper into the NAD World, hopeful interventions

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By James P Watson with contributions and assistance by Vince Giuliano This is Part 2 of what will likely be a six-part series of blog entries related to the metabolic cofactor NAD+ and what goes on in the NAD World,  … Continue reading

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NAD+ an emerging framework for health and life extension — Part 1: The NAD World

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By Vince Giuliano with inputs from  James P. Watson Accelerated by the publication in December 2013 of a seminal paper by David Sinclair and his US and Australian colleagues(ref), there has been increasing interest and excitement about the prospects of … Continue reading

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Glucosamine for longevity

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By Vince Giuliano with important contributions by James P Watson Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and … Continue reading

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Nuclear Aging: The View from the Telomere end of the Chromosome – Part 3 – Telomere Molecular Biology and GUT implications – The two faces of P53

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By James P Watson with editorial assistance and comments by Vince Giuliano This is Part 3 of 3 in the series The View from the Telomere end of the Chromsome.  Because of the length of the telomere story, we divided … Continue reading

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Update on C60 fullerenes in olive oil

By Vince Giuliano and James P Watson Image source More than a year has passed since publication of the November 2012 blog entry Buckyballs, health and longevity – state of knowledge, It will be another year or two before we … Continue reading

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Jim Watson’s “Top 12” List of “Things I Learned about Aging” in 2013

By James P Watson with editorial assistance from Vince Giuliano In the style of David Letterman’s “top 10 list” from late night TV, I am listing my own list of the most important things that I personally learned in 2013 … Continue reading

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Editorial: 13 personal health and longevity science headlines for 2013

By Vince Giuliano with comments by James P Watson We have come to the end of a year and a start of another, and this has led me to musing about what I have learned in 2013. I have been … Continue reading

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PART 1: Slaying Two Dragons with One Stone – How to Prevent Cancer and Aging with the Same Strategy

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Image source By James Watson and Vince Giuliano This is the first part of a three-part series of blog entries on the epigenetic’s of cancer and aging and how those two deadly dragons can be seriously slow down or stopped … Continue reading

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Mitochondria Part 2: Mitochondrial Responses to Stress: Mitochondrial Signaling: Survival and Death Pathways

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Written by James Watson, with major contributions by Vince Giuliano Introduction – Mitochondrial Roles in the Cell This is the second part in a series of blog entries examining the roles of mitochondria in key biological activities.  For additional background … Continue reading

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