Search Results for: DNA methylation

ON AGING

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By Vince Giuliano June 27 1017   Once in a while over the years I take a break from blog research and writing as I have done recently.  When I come back to the research and writing after such a … Continue reading

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Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions: 1)Inflammation, 2)Genomic Instability (p53), and 3)Oxidative stress (Nrf2)

By James Watson, with contributions and editing by Vince Giuliano We promised a major series of blog entries related to inflammation back in May 2016.    We said we would do that through narrating a number of inter-related stories many of … Continue reading

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G-qaudruplexes

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By James P Watson with editorial help and selected contributions by Vince Giuliano Image source Human telomeric G-quadruplex structure  Introduction by Vince Giuliano If you are new to G-quadraplexes, I can appreciate reader resistance to confronting the intellectual challenge of … Continue reading

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Part 4 of the NAD world: the NQ01 gene, the Warburg effect, SIRT 1 and inflammation, and possible interventions

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By James P Watson with contributions and editorial assistance by Vince Giuliano This Part 4 blog entry goes even further into the extended NAD story, examining important subtopics: The ratio NAD+/NADH in cells and the body, which may be as … Continue reading

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NAD+ an emerging framework for life health and life extension — Part 2: Deeper into the NAD World, hopeful interventions

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By James P Watson with contributions and assistance by Vince Giuliano This is Part 2 of what will likely be a six-part series of blog entries related to the metabolic cofactor NAD+ and what goes on in the NAD World,  … Continue reading

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What do we need to do to live longer, healthier lives? An editorial tale of cars and people

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By Vince Giuliano Can we expect to live longer and longer as the first part of this century rolls by? I think so, probably by a large amount. We about doubled our human lifespans in the course of the last … Continue reading

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FIVE-YEAR PROGRESS REPORT ON MAJOR TRENDS IMPACTING ON LONGEVITY.

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By Vince Giuliano This is a progress report on the changing state of human longevity during the five-year lifespan of this blog.  It reviews major trends and forces impacting on our lifespans, both scientific and social.  Longevity can be viewed … Continue reading

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Shedding new light on circadian rhythms

By Vince Giuliano with inputs from James P Watson, Victor, and Melody Winnig Many of our most basic biological processes including gene activation are affected by circadian and other body and cell-level clock rhythms. In January 2012, Victor posted a blog … Continue reading

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Nuclear Aging: The View from the Telomere end of the Chromosome – Part 2 – Telomere Molecular Biology

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By James P Watson with editorial assistance and a few comments by Vince Giuliano This is Part 2 of 3 in the series The View from the Telomere end of the Chromsome.  Because of the length of the extended telomere story, we … Continue reading

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Nuclear Aging: The View from the Telomere end of the Chromosome Part 1 – context, history, and about telomere lengths

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By James P Watson with Preface and editorial assistance by Vince Giuliano Preface by Vince Giuliano According to the latest theories of cosmology, the universe has no center.  However, anyplace in the universe, including where we are on Earth, can … Continue reading

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